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Figure 5 | Arthritis Research & Therapy

Figure 5

From: Egr-1 inhibits the expression of extracellular matrix genes in chondrocytes by TNFα-induced MEK/ERK signalling

Figure 5

Proximal promoters and overlapping binding regions for Sp1 and Egr-1. Proximal promoters of rat type II collagen and aggrecan, but not of link protein, have overlapping binding regions for Sp1 and Egr-1. Upstream regions of (a) the rat type II collagen, (b) aggrecan and (c) link protein were analysed by TRANSFAC [26] for transcription factor binding sites. (a) and (b) Proximal to the transcriptional start site, the type II collagen and aggrecan promoters have multiple putative Sp1 (underlined) and Egr-1 binding sites (bold), some of which are found in overlapping regions.

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