Gene | Accession number | Description | Fold change | Basal MEK/ERK dependent | ||
---|---|---|---|---|---|---|
U0126 | TNF | TNF + U0126 | ||||
TNFα-regulated MEK/ERK dependent | ||||||
Hyaluronic acid binding activity | ||||||
Agc1 | [GenBank:NM_022190] | Aggrecan 1 | 1.14 | 0.68 | 1.08 | |
Hapln1 | [GenBank:NM_019189] | Hyaluronan and proteoglycan link protein 1 | 1.15 | 0.65 | 0.96 | |
Collagenase or metallopeptidase activity | ||||||
Mmp-12 | [GenBank:NM_053963] | Matrix metallopeptidase 12 | 0.67 | 2.92 | 0.93 | |
Mmp-9 | [GenBank:NM_031055] | Matrix metallopeptidase 9 | 0.87 | 1.89 | 1.01 | |
Metallopeptidase activity | ||||||
Arts1, ERAP1, Appils | [GenBank:NM_030836] | Type 1 TNF receptor shedding aminopeptidase regulator | 1.33 | 1.78 | 1.55 | |
Complement binding | ||||||
C4bpa | [GenBank:NM_012516] | Complement component 4 binding protein, alpha | 1.01 | 2.19 | 1.35 | |
Others | ||||||
Amigo2 | [GenBank:NM_182816] | Adhesion molecule with Ig-like domain 2 | 0.99 | 1.55 | 1.26 | |
Cacna2d3 | [GenBank:NM_175595] | Calcium channel, voltage-dependent, α2/δ3 subunit | 0.82 | 1.56 | 0.99 | |
Cd68 (predicted) | [GenBank:NM_001031638] | CD68 antigen | 1.01 | 1.80 | 1.14 | |
Cgref1, Cgr11 | [GenBank:NM_139087] | Cell growth regulator with EF hand domain 1 | 1.01 | 0.61 | 0.83 | |
Cyp4b1 | [GenBank:NM_016999] | Cytochrome P450, family 4, subfamily b, polypeptide 1 | 1.71 | 1.72 | 1.83 | |
Gm1960, Cinc2, Cinc-2 | [GenBank:NM_138522] | Gene model 1960 (NCBI) | 0.94 | 2.38 | 1.27 | |
TNFα-regulated MEK/ERK independent | ||||||
Peptidase activity | ||||||
Adam17; TACE | [GenBank:NM_020306] | A disintegrin and metalloproteinase domain 17 (TNF, alpha, converting enzyme) | 0.93 | 1.64 | 1.41 | |
Mmp13 | [GenBank:XM_343345] | Matrix metallopeptidase 13 | 0.33 | 6.80 | 1.10 | * |
Ctsc | [GenBank:NM_017097] | Cathepsin C | 1.18 | 2.84 | 1.72 | |
Serpinb2, Pai2a | [GenBank:NM_021696] | Serine (or cysteine) proteinase inhibitor, clade B, member 2 | 0.75 | 3.47 | 1.68 | |
Plat, tPA, PATISS | [GenBank:NM_013151] | Plasminogen activator, tissue | 0.94 | 3.22 | 1.56 | |
Plau, UPAM | [GenBank:NM_013085] | Plasminogen activator, urokinase | 1.36 | 2.23 | 2.87 | |
C1s, r-gsp | [GenBank:NM_138900], [GenBank:XM_575664] | Complement component 1, s subcomponent | 1.05 | 1.98 | 1.88 | |
Cpxm1 (predicted) | [GenBank:XM_215840] | Carboxypeptidase × 1 (M14 family) (predicted) | 1.21 | 3.11 | 1.84 | |
Mmp3 | [GenBank:NM_133523] | Matrix metallopeptidase 3 | 0.36 | 10.26 | 3.41 | * |
Chemokine activity | ||||||
Ccl5, Scya5, Rantes | [GenBank:NM_031116] | Chemokine (C-C motif) ligand 5 | 0.90 | 4.26 | 1.37 | |
Cxcl12, Sdf1 | [GenBank:NM_001033882], [GenBank:NM_001033883], [GenBank:NM_022177] | Chemokine (C-X-C motif) ligand 12 | 0.75 | 2.17 | 1.33 | |
Ccl20, ST38, Scya20 | [GenBank:NM_019233] | Chemokine (C-C motif) ligand 20 | 0.65 | 12.86 | 5.82 | |
Cx3cl1, Cx3c, Scyd1 | [GenBank:NM_134455] | Chemokine (C-X3-C motif) ligand 1 | 0.72 | 4.41 | 2.95 | |
Cxcl1, Gro1, CINC-1 | [GenBank:NM_030845] | Chemokine (C-X-C motif) ligand 1 | 0.55 | 9.18 | 3.61 | * |
Cxcl10, IP-10, Scyb10 | [GenBank:NM_139089] | Chemokine (C-X-C motif) ligand 10 | 0.88 | 2.40 | 3.22 | |
Ccl2, MCP-1, Scya2, Sigje | [GenBank:NM_031530] | Chemokine (C-C motif) ligand 2 | 0.68 | 32.14 | 22.59 | |
Cytokine or growth factor activity | ||||||
Bmp2 | [GenBank:NM_017178] | Bone morphogenetic protein 2 | 0.89 | 1.61 | 1.53 | |
Gdf10 | [GenBank:NM_024375] | Growth differentiation factor 10 | 0.59 | 0.30 | 0.21 | * |
Csf1 | [GenBank:NM_023981] | Macrophage colony-stimulating factor 1 | 0.86 | 2.37 | 2.17 | |
Ifngr1 | [GenBank:NM_053783] | IFNγ receptor 1 | 0.96 | 1.97 | 1.39 | |
Spp1, OSP | [GenBank:NM_012881] | Secreted phosphoprotein 1 | 0.97 | 4.21 | 1.98 | |
Vegfa | [GenBank:NM_031836] | Vascular endothelial growth factor A | 1.11 | 1.80 | 1.43 | |
ATPase activity | ||||||
Tap1, Cim, Abcb2 | [GenBank:NM_032055] | Transporter 1, ATP-binding cassette, subfamily B (MDR/TAP) | 1.22 | 1.91 | 2.24 | |
Tap2, Cim, Abcb3 | [GenBank:NM_032056] | Transporter 2, ATP-binding cassette, subfamily B (MDR/TAP) | 1.01 | 2.11 | 1.91 | |
G-protein coupled receptor binding | ||||||
Ramp1 | [GenBank:NM_031645] | Receptor (calcitonin) activity modifying protein 1 | 2.16 | 0.53 | 0.93 | |
Ramp2 | [GenBank:NM_031646] | Receptor (calcitonin) activity modifying protein 2 | 0.88 | 1.57 | 1.31 |