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Figure 8 | Arthritis Research & Therapy

Figure 8

From: The response to oestrogen deprivation of the cartilage collagen degradation marker, CTX-II, is unique compared with other markers of collagen turnover

Figure 8

Selective effect of oestrogen on one of the two pathways for type II collagen breakdown. The evidence for two type II collagenolytic mechanisms, one related to cysteine proteinases and Helix-II, the other related to matrix metalloproteinase (MMPs) and CTX-II comes from Charni and colleagues [34]. The evidence for the selective effect of oestrogen on mechanism two comes from the present study. The evidence for the association of mechanism two with eNOS comes from Sniekers and colleagues [6], Grassi and colleagues [45] and Gurjar and colleagues [46].

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