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Figure 5 | Arthritis Research & Therapy

Figure 5

From: Dissection of a locus on mouse chromosome 5 reveals arthritis promoting and inhibitory genes

Figure 5

Collagen-induced arthritis (CIA) in Eae39 congenic mice. (a) A schematic outline of overlapping congenic fragments confined to the C5 interval. Black = two B10.RIII alleles; grey = heterozygous. (b - f) CIA development in C5, C6, C9, C10 and C11 congenic mice, and littermate controls. The littermate control group comprises all mice homozygous for B10.RIII alleles (b/b) from the breeding of the congenic mice. The different littermate control groups' data were pooled because they had similar disease progression. The C5 and C9 congenic fragment have been generated from C4 (Figure 4) by backcrossing to the B10.RIII parental strain and subsequently intercrossing the offspring. The C6, C10 and C11 were generated by backcrossing C5 congenic mice to the B10.RIII parental strain followed by intercrossing of the offspring. Stars indicate significant differences in mean arthritis score: * p < 0.05, ** p < 0.01.

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