Dissection of a locus on mouse chromosome 5 reveals arthritis promoting and inhibitory genes

Table 5 Anti-collagen type II antibody responses in C6, C9, C10 and C11 congenic mice

Antibody isotype	B10.RIII^a	C6	C9	C10	C11
IgG1	2046^b ± 276^c	1567 ± 265	1354 ± 193	2520 ± 388*	2868 ± 576*
IgG2c	2337 ± 262	1754 ± 212	2031 ± 420	2859 ± 477	4096 ± 692**
IgG3	1873 ± 141	1364 ± 273	2144 ± 473	2483 ± 370	3021 ± 409**
IgTot	2705 ± 300	2038 ± 291	2439 ± 661	4130 ± 551**	3696 ± 543**

^aB10.RIII = littermate controls (n = 64) for mice with the different congenic fragments. The congenic intervals are outlined in Figure 5a. C6 (n = 14), C9 (n = 9), C10 (n = 15), C11 (n = 17).
^bArbitrary antibody concentration in serum. Blood was collected day 21 after immunisation. Anti-collagen type II antibodies in non-immunized mice are not detectable.
^cMean ± standard error of the mean
Statistics was calculated with Mann-Whitney U test, * p < 0.05, **p < 0.01

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