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Figure 3 | Arthritis Research & Therapy

Figure 3

From: Selective amplification of glucocorticoid anti-inflammatory activity through synergistic multi-target action of a combination drug

Figure 3

Prednisolone and dipyridamole combine to suppress collagen-induced arthritis in vivo. Collagen-induced arthritis (CIA) was developed in Lewis rats for 10 days before oral daily dosing with compounds as indicated (mg/kg) for the next 17 days. Change in hind limb tibiotarsal joint diameter relative to the day 3 measurement is reported (a) over the course of the study and (b) at study completion. *P < 0.001 versus the CIA control; aP = 0.29, bP = 0.10, cP = 0.14, dP = 0.004 versus the combination. (c) CIA was induced in Louvain rats for 10 days and test agents were administered orally once daily from days 10 to 28, as indicated (mg/kg). Arthritis severity was scored daily based on erythema and swelling. *P < 0.001 versus the CIA control; aP = 0.0003, bP = 0.001, cP = 0.15, dP = 0.12 versus the combination at day 28. (d) Hind limbs were scored by radiographic joint index after the completion of the study. **P < 0.0001, *P < 0.01 versus the CIA control; aP = 0.005, bP = 0.17, cP = 0.84, dP = 0.01 versus the combination at day 28. Dipyridamole was dosed at 150 mg/kg. Error bars are ± standard error of the mean, and statistical comparison is by analysis of variance with Tukey. Dp, dipyridamole; Pd, prednisolone.

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