Skip to main content

Table 1 Microarray data mining

From: Antirheumatic drug response signatures in human chondrocytes: potential molecular targets to stimulate cartilage regeneration

Analysis Finding
RA-related genes in human chondrocytes differentially expressed in human chondrocytes that were stimulated with supernatant of RASFs versus NDSF stimulation - 110 pharmacological marker genes and relevant pathways of RA-related chondrocyte dysfunction
KEGG pathway analysis  
Antirheumatic drug response signatures in human chondrocytes - Mechanism of drug action
Differential expression of RA-related genes in human chondrocytes due to antirheumatic treatment of RASFs (stimulation of human chondroctyes with supernatant of drug-treated RASFs versus stimulation with supernatant of untreated RASFs) - 94 pharmacological marker genes and relevant pathways for stimulation of cartilage regeneration and suppression of inflammation
Hierarchical clustering analysis, principal components analysis, and KEGG pathway analysis  
Validation of microarray data - Microarray data were confirmed for selected genes/proteins
- Real-time reverse transcription-polymerase chain reaction  
- Enzyme-linked immunosorbent assay  
  1. KEGG, Kyoto Encyclopaedia of Genes and Genomes; NDSF, healthy donor synovial fibroblast; RA, rheumatoid arthritis; RASF, rheumatoid arthritis synovial fibroblast.