Table 1 Microarray data mining
Analysis | Finding |
|---|---|
RA-related genes in human chondrocytes differentially expressed in human chondrocytes that were stimulated with supernatant of RASFs versus NDSF stimulation | - 110 pharmacological marker genes and relevant pathways of RA-related chondrocyte dysfunction |
KEGG pathway analysis | |
Antirheumatic drug response signatures in human chondrocytes | - Mechanism of drug action |
Differential expression of RA-related genes in human chondrocytes due to antirheumatic treatment of RASFs (stimulation of human chondroctyes with supernatant of drug-treated RASFs versus stimulation with supernatant of untreated RASFs) | - 94 pharmacological marker genes and relevant pathways for stimulation of cartilage regeneration and suppression of inflammation |
Hierarchical clustering analysis, principal components analysis, and KEGG pathway analysis | |
Validation of microarray data | - Microarray data were confirmed for selected genes/proteins |
- Real-time reverse transcription-polymerase chain reaction | |
- Enzyme-linked immunosorbent assay |