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Table 3 Comparison of PM/Scl-100 antibody-positive versus-negative patients

From: Antibodies against PM/Scl-75 and PM/Scl-100 are independent markers for different subsets of systemic sclerosis patients

Disease manifestation anti-PM/Scl-100-positive
(n = 20)
anti-PM/Scl-100-negative
(n = 261)
P value Sensitivity, percentagea Specificity, percentageb
Digital ulcersc 12 (60.0) 100 (38.5) 0.095 10.7 95.2
Lung fibrosisc 11 (55.0) 87 (33.5) 0.086 11.2 95.1
CK elevationc 7 (35.0) 30 (11.5) 0.009 18.9 94.7
Esophago-gastral involvementc 11 (55.0) 204 (78.5) 0.026 5.1 86.2
Small intestinal involvementc 3 (15.0) 100 (38.5) 0.052 2.9 90.4
Colon involvementc 4 (20.0) 115 (44.2) 0.037 3.4 90.1
  1. Clinical differences between antibody-positive and -negative patients were shown only when P values of below 0.1 were detected. a,bCalculations of sensitivity and specificity are analogous to those in Table 2. cValues displayed are numbers of patients (percentages). CK, creatine kinase.