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Table 1 Demographic and clinical characteristics in systemic lupus erythematosus patients with IgM anti-CMV(+) versus IgM anti-CMV(-)

From: Reduced IgG anti-small nuclear ribonucleoprotein autoantibody production in systemic lupus erythematosus patients with positive IgM anti-cytomegalovirus antibodies

 

All patients

IgM anti-CMV(+) patients

IgM anti-CMV(-)

IgG anti-CMV(+) patients

n

59

20a

39

Age (years)

36.7 ± 14.1 (13 to 72)

34.3 ± 15.1 (14 to 72)

37.9 ± 13.6 (13 to 64)

Sex (female/male)

56/3

18/2

38/1

Disease status

   

   Disease duration (years)

7.4 ± 6.4 (0.1 to 36)

9.4 ± 8.0 (2 to 36)

6.5 ± 5.3 (0.1 to 23)

   Age at diagnosis (years)

29.2 ± 12.1 (7 to 57)

24.9 ± 10.9* (7 to 57)

31.5 ± 12.3* (12 to 57)

Clinical assessment

   

   Mexican SLEDAI

2.88 ± 2.97 (0.0 to 12)

3.30 ± 3.26 (0.0 to 10)

2.67 ± 2.83 (0.0 to 12)

   SLICC

0.76 ± 1.75 (0.0 to 12)

1.11 ± 2.75 (0.0 to 12)

0.59 ± 0.97 (0.0 to 3)

Laboratory data

   

   Rheumatoid factor (IU/ml)

18.2 ± 20.9 (2 to 108)

21.3 ± 29.0 (2 to 108)

16.7 ± 15.5 (3 to 60)

   Soluble IL-10 (pg/ml)

27.9 ± 54.8 (9.31 to 422)

39.4 ± 90.5 (11.7 to 422)

22.0 ± 19.4 (9.3 to 126.7)

   IgG CMV (U)

233.7 ± 46.3 (3.5 to 250)

233.6 ± 55.3 (3.5 to 250)

233.8 ± 41.8 (70 to 250)

   White blood cells (/μl)

5,782 ± 2,008 (2,870 to 12,100)

5,413 ± 1,713 (2,900 to 8,700)

5,962 ± 2,135 (2,870 to 12,100)

   Lymphocyte (/μl)

1493 ± 688 (154 to 3,400)

1450 ± 676 (154 to 2,890)

1515 ± 702 (269 to 3,400)

   Platelet (× 103/μl)

273.8 ± 63.9 (137 to 445)

262.8 ± 81.7 (137 to 445)

279.2 ± 53.7 (167 to 385)

Treatment

   

   Azathioprine (%)

59

47

64

   Methotrexate (%)

21

16

23

   Cyclophosphamide (%)

5

5

5

   Immunosuppressive therapyb (%)

79

63

87

   Chloroquine (%)

52

53

51

   On steroid (%)

57

68

51

   Steroid dose (prednisone mg/day)

4.7 ± 6.1

5.9 ± 5.9

4.1 ± 6.2

   Prednisone ≥ 10 mg/day (%)

17

26

13

  1. Data presented as the mean ± standard deviation (minimum to maximum). All values were compared between the IgM anti-CMV(+) group and the IgM anti-CMV(-)IgG(+) group using the Mann–Whitney test (values) or Fisher's exact test (%). P values were not significant (P > 0.05) except for age at diagnosis (*P = 0.048). CMV, cytomegalovirus; SLEDAI, Systemic Lupus Erythematosus Disease Activity Index; SLICC, Systemic Lupus International Collaborating Clinics. aInformation for treatment was available in 19 patients in this group. bAzathioprine, methotrexate, or cyclophosphamide.