Skip to main content

Table 1 Demographic and clinical characteristics in systemic lupus erythematosus patients with IgM anti-CMV(+) versus IgM anti-CMV(-)

From: Reduced IgG anti-small nuclear ribonucleoprotein autoantibody production in systemic lupus erythematosus patients with positive IgM anti-cytomegalovirus antibodies

  All patients IgM anti-CMV(+) patients IgM anti-CMV(-)
IgG anti-CMV(+) patients
n 59 20a 39
Age (years) 36.7 ± 14.1 (13 to 72) 34.3 ± 15.1 (14 to 72) 37.9 ± 13.6 (13 to 64)
Sex (female/male) 56/3 18/2 38/1
Disease status    
   Disease duration (years) 7.4 ± 6.4 (0.1 to 36) 9.4 ± 8.0 (2 to 36) 6.5 ± 5.3 (0.1 to 23)
   Age at diagnosis (years) 29.2 ± 12.1 (7 to 57) 24.9 ± 10.9* (7 to 57) 31.5 ± 12.3* (12 to 57)
Clinical assessment    
   Mexican SLEDAI 2.88 ± 2.97 (0.0 to 12) 3.30 ± 3.26 (0.0 to 10) 2.67 ± 2.83 (0.0 to 12)
   SLICC 0.76 ± 1.75 (0.0 to 12) 1.11 ± 2.75 (0.0 to 12) 0.59 ± 0.97 (0.0 to 3)
Laboratory data    
   Rheumatoid factor (IU/ml) 18.2 ± 20.9 (2 to 108) 21.3 ± 29.0 (2 to 108) 16.7 ± 15.5 (3 to 60)
   Soluble IL-10 (pg/ml) 27.9 ± 54.8 (9.31 to 422) 39.4 ± 90.5 (11.7 to 422) 22.0 ± 19.4 (9.3 to 126.7)
   IgG CMV (U) 233.7 ± 46.3 (3.5 to 250) 233.6 ± 55.3 (3.5 to 250) 233.8 ± 41.8 (70 to 250)
   White blood cells (/μl) 5,782 ± 2,008 (2,870 to 12,100) 5,413 ± 1,713 (2,900 to 8,700) 5,962 ± 2,135 (2,870 to 12,100)
   Lymphocyte (/μl) 1493 ± 688 (154 to 3,400) 1450 ± 676 (154 to 2,890) 1515 ± 702 (269 to 3,400)
   Platelet (× 103/μl) 273.8 ± 63.9 (137 to 445) 262.8 ± 81.7 (137 to 445) 279.2 ± 53.7 (167 to 385)
Treatment    
   Azathioprine (%) 59 47 64
   Methotrexate (%) 21 16 23
   Cyclophosphamide (%) 5 5 5
   Immunosuppressive therapyb (%) 79 63 87
   Chloroquine (%) 52 53 51
   On steroid (%) 57 68 51
   Steroid dose (prednisone mg/day) 4.7 ± 6.1 5.9 ± 5.9 4.1 ± 6.2
   Prednisone ≥ 10 mg/day (%) 17 26 13
  1. Data presented as the mean ± standard deviation (minimum to maximum). All values were compared between the IgM anti-CMV(+) group and the IgM anti-CMV(-)IgG(+) group using the Mann–Whitney test (values) or Fisher's exact test (%). P values were not significant (P > 0.05) except for age at diagnosis (*P = 0.048). CMV, cytomegalovirus; SLEDAI, Systemic Lupus Erythematosus Disease Activity Index; SLICC, Systemic Lupus International Collaborating Clinics. aInformation for treatment was available in 19 patients in this group. bAzathioprine, methotrexate, or cyclophosphamide.