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Table 1 Clinical and demographic characteristics of the systemic sclerosis (SSc) cohort (Charité University)

From: Diagnostic value of anti-topoisomerase I antibodies in a large monocentric cohort

  Diffuse SSc Limited SSc SSc sine scleroderma Overlap Mixed connective tissue disease Undifferentiated connective tissue disease All patients
Anti-topoisomerase I (LIA) 58 (60.4) 7 (6.2) 1 (25.0) 1 (2.6) 0 0 67 (23.9)
Anti-topoisomerase I (ELISA) 57 (59.4) 6 (5.3) 1 (25.0) 1 (2.6) 0 0 65 (23.2)
Number 96 113 4 38 13 16 280
Age (years) 53 ± 14.5 60 ± 11.3 54 ± 12.7 52 ± 13.3 52 ± 13.5 56 ± 10.7 56 ± 13.2
Duration of Raynaud's phenomenon (years) 9 ± 10.6 14 ± 13.6 18 ± 18.47 8 ± 7.4 16 ± 10.4 11 ± 9.3 12 ± 11. 6
Duration of non-Raynaud's phenomenon symptoms 7.8 ± 1.6 9.5 ± 1.39 6 ± 10.8 8.8 ± 2.2 9.1 ± 5.5 9.3 ± 6.3 8.7 ± 7.6
Duration since disease diagnosis (years) 6 ± 7.38 8 ± 7.4 3 ± 2.6 6 ± 5.17 9.1 ± 5.5 7 ± 7.28 7 ± 7.38
Female/male 79/17 105/8 2/2 28/10 13/0 16/0 243/37
mRSS 13.2 ± 9.6 5.2 ± 4.2 1.5 ± 1.1 6.7 ± 7.5 1.6 ± 1.8 0.8 ± 1.1 7.6 ± 8.0
Digital ulcers 52 (54.2) 38 (33.6) 2 (50) 14 (36.8) 4 (30.8) 2 (12.5) 112 (40.0)
Lung fibrosis 57 (59.4) 16 (14.2) 3 (75) 16 (42.1) 4 (30.8) 2 (12.5) 98 (35.0)
DLCO by a single breath (%) 64.9 ± 21.9 76,8 ± 17.5 56.6 ± 12.8 64.2 ± 22.4 75.3 ± 17.8 75.4 ± 17.1 70.5 ± 20.5
Mean FVC (%) 81.7 ± 18.93 96.7 ± 15.2 87.5 ± 30.7 84.0 ± 19.2 92.9 ± 23.5 92 ± 18.0 89,2 ± 19.
Contractures 78 (81.3) 62 (54.9) 2 (50) 23 (60.5) 4 (30.8) 3 (18.8) 172 (61.4)
Pulmonary arterial hypertension 22 (22.9) 22 (19.5) 2 (50) 9 (23.7) 4 (30.8) 1 (6.3) 60 (21.4)
Renal involvement 17 (17.7) 22 (19.5) 1 (25) 10 (26.3) 4 (30.8) 2 (12.5) 56 (20)
Renal crisis 10 (10.4) 3 (2.7), n = 112 1 (25) 1 (2.6) 0 1 (6.3) 16 (5.7), n = 279
Cardiac involvement 47 (49.0) 35 (31.0) 3 (75) 19 (50) 6 (46.2) 4 (25) 117 (40.7)
Skin involvement 94 (98.9) 105 (92.9) 3 (75) 32 (84.2) 7 (53.8) 7 (43.8) 248 (88.9)
Raynaud's phenomenon 95 (99) 110 (97.3) 4 (100) 38 (100) 12 (92.3) 13 (81.3) 272 (97.1)
  1. Data presented as mean ± standard deviation or n (%). DLCO, predicted diffusion capacity; FVC, predicted forced vital capacity; LIA, line immunoblot assay; mRSS, modified Rodnan Skin Score.