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Table 2 Sensitivity and specificity of anti-topoisomerase I antibodies

From: Diagnostic value of anti-topoisomerase I antibodies in a large monocentric cohort

Panel n Line immunoblot assay ELISA
Diffuse systemic sclerosisa 96 58 (60.4%) 57 (59.4)
Limited systemic sclerosisa 113 7 (6.2%) 6 (5.3%)
Systemic sclerosis sine sclerodermaa 4 1 (25%) 1 (25%)
Overlapa 38 1 (2.6%) 1 (2.6%)
Mixed connective tissue diseasea 13 0 0
Undifferentiated connective tissue diseasea 16 0 0
   Sensitivitya 280 67 (23.9%) 65 (23.2%)
Myositisb 26 0 (100%) 0 (100%)
Systemic lupus erythematosusb 208 0 (100%) 0 (100%)
Sjögren's syndromeb 88 0 (100%) 0 (100%)
Rheumatoid arthritisb 165 2 (98.8%) 1 (99.4%)
   Specificityb 487 2 (99.6%) 1 (99.8%)
  1. aData presented as number of patients positive in the respective test (percentage within the respective patient cohort). bData presented as number of patients positive in the respective test (percentage of negative results within the respective control cohort).