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Table 1 Studies evaluating the risk of coronary heart disease in rheumatoid arthritis

From: The inextricable link between atherosclerosis and prototypical inflammatory diseases rheumatoid arthritis and systemic lupus erythematosus

[Reference] (year)

Study design

RA definition

n

Estimated risk

[18] (2001)

Prospective cohort

ACR 1987 criteria

236

3.86-fold of combined CV events (MI + revascularization + stroke)

[4] (2003)

Prospective cohort

ACR 1987 criteria

525

2-fold risk for MI

1.48-fold risk for stroke

RA >10 years: 3-fold risk for MI

[84] (2003)

Cross-sectional survey

Rheumatologist diagnosis

9,093

2.15-fold risk for MI

[19] (2003)

Prospective cohort

Physician diagnosis

11,633

1.6-fold risk for MI

[5] (2005)

Retrospective cohort

ACR 1987 criteria

603

2-fold risk for MI

6-fold risk for unrecognized MI

2-fold risk sudden death

[85] (2007)

Retrospective cohort

ACR 1987 criteria

239

0.1% to 0.3%/year MI

0.07%/year stroke

[2] (2008)

Retrospective cohort

Rheumatologist diagnosis

4,363

3.2% prevalence MI

1.9% prevalence stroke

  1. ACR, American College of Rheumatology; CHD, coronary heart disease; CVD, cardiovascular disease; MI, myocardial infarction; RA, rheumatoid arrthritis.