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Table 2 Relationship between adiposity measures and risk of primary joint replacement

From: Relationship between body adiposity measures and risk of primary knee and hip replacement for osteoarthritis: a prospective cohort study

Variable Number of cases in each quartile Hazard ratio 95% confidence interval P value
Weight (kg)     
   Q1 (F <59.7, M <73.0) 136 (9,756) 1.00   
   Q2 (F 59.7 to 66.2, M 73.0 to 79.7) 202 (9,485) 1.58 1.27 to 1.97  
   Q3 (F 66.2 to 74.6, M 79.7 to 87.4) 269 (9,418) 2.17 1.77 to 2.67  
   Q4 (F >74.6, M >87.4) 401 (9,329) 3.44 2.83 to 4.18  
   Linear model (per 10 kg)   1.42 1.36 to 1.48 <0.001
Body mass index (kg/m2)     
   Q1 (F <23.2, M <24.7) 128 (9,663) 1.00   
   Q2 (F 23.2 to 25.9, M 24.7 to 26.8) 211 (9,511) 1.65 1.32 to 2.05  
   Q3 (F 25.9 to 29.3, M 26.8 to 29.2) 302 (9,458) 2.48 2.01 to 3.05  
   Q4 (F >29.3, M >29.2) 367 (9,354) 3.44 2.80 to 4.22  
   Linear model (per 5 kg/m2)   1.60 1.51 to 1.70 <0.001
Waist circumference (cm)     
   Q1 (F <71.0, M <87.0) 136 (9,943) 1.00   
   Q2 (F 71.0 to 78.0, M 87.0 to 93.0) 222 (9,612) 1.59 1.29 to 1.97  
   Q3 (F 78.0 to 87.0, M 93.0 to 99.0) 290 (9,399) 2.07 1.68 to 2.54  
   Q4 (F >87.0, M >99.0) 360 (9,025) 2.77 2.26 to 3.39  
   Linear model (per 10 cm)   1.38 1.31 to 1.45 <0.001
Waist-to-hip ratio     
   Q1 (F < 0.74, M < 0.88) 193 (9,553) 1.00   
   Q2 (F 0.74 to 0.78, M 0.88 to 0.92) 234 (9,516) 1.13 0.94 to 1.37  
   Q3 (F 0.78 to 0.82, M 0.92 to 0.96) 264 (9,498) 1.23 1.02 to 1.48  
   Q4 (F > 0.82, M > 0.96) 317 (9,410) 1.46 1.21 to 1.76  
   Linear model (per 0.1 unit)   1.23 1.12 to 1.35 <0.001
Fat mass (kg)     
   Q1 (F <21.1, M <18.4) 125 (9,586) 1.00   
   Q2 (F 21.1 to 26.5, M 18.4 to 23.0) 209 (9,502) 1.71 1.37 to 2.13  
   Q3 (F 26.5 to 32.9, M 23.0 to 27.9) 273 (9,438) 2.26 1.83 to 2.80  
   Q4 (F >32.9, M >27.9) 398 (9,312) 3.51 2.87 to 4.30  
   Linear model (per 10 kg)   1.61 1.52 to 1.71 <0.001
Percentage fat (%)     
   Q1 (F <35.3, M <25.0) 143 (9,568) 1.00   
   Q2 (F 35.3 to 40.1, M 25.0 to 28.9) 205 (9,506) 1.45 1.17 to 1.80  
   Q3 (F 40.1 to 44.6, M 28.9 to 32.6) 260 (9,451) 1.86 1.51 to 2.28  
   Q4 (F >44.6, M >32.6) 397 (9,313) 2.99 2.46 to 3.63  
   Linear model (per 10%)   2.01 1.81 to 2.22 <0.001
  1. All models using sex-specific quartiles of adiposity measures adjusted for age, gender, country of birth, and highest level of education. All models using continuous adiposity measures adjusted for age, country of birth, and highest level of education, stratifying by gender, representing an approximate change of one standard deviation for each of the adiposity measures. Q1, first quartile; Q2, second quartile; Q3, third quartile; Q4, fourth quartile; F, female; M, male.