Ingenuity pathway analysis of proteins displaying alterations in expression patterns following infliximab treatment in patients deemed to be responders. (See Results for response definitions.) The network diagram shows the relationship between the indicated proteins by solid or dashed lines, which represent direct or indirect interactions, respectively. Up-regulated proteins are shown in red, and down-regulated proteins are shown in green. The network is centred on tumour necrosis factor-alpha (TNF-α) and nuclear factor-kappa-B (NF-κB) as reflected by the number of interactions associated with these proteins.