Figure 4
From: The effects of infliximab therapy on the serum proteome of rheumatoid arthritis patients
Ingenuity pathway analysis of proteins displaying alterations in expression patterns following infliximab treatment in patients deemed to be non-responders. (See Results for response definitions.) A network analysis of the differentially expressed proteins in the non-responder group indicates that, as with the responder network shown in Figure 2, tumour necrosis factor (TNF) is at the centre of the network but the down-regulated proteins are more distal, whereas more proximal proteins such as C-reactive protein (CRP) are up-regulated.