Skip to main content

Table 2 Change in total (L+D) amino acid composition with age in normal cartilage, osteoarthritic articular, and meniscal cartilages

From: Amino acid racemization reveals differential protein turnover in osteoarthritic articular and meniscal cartilages

  

Amino acid

  

Asx

Ser

Leu

Ile

Glx

Ala

Normal articular cartilage

Mean (nmol/mg)

157.3

104.8

87.4

37.2

252.5

262

 

r 2

0.054

0.037

0.042

0.065

0.060

0.090

 

Slope

-0.456

-0.233

-0.203

-0.120

-0.796

-1.040

 

P value

0.327

0.418

0.399

0.293

0.297

0.198

OA articular cartilage

Mean (nmol/mg)

99.5

67.7

56.0

23.2

159.1

165.7

 

r 2

0.076

0.070

0.028

0.081

0.056

0.059

 

Slope

0.419

0.278

0.237

0.196

0.532

0.645

 

P value

0.141

0.157

0.377

0.129

0.208

0.196

OA meniscal cartilage

Mean (nmol/mg)

100.4

74.6

53.4

23.7

140.5

180.4

 

r 2

0.208

0.194

0.143

0.144

0.194

0.232

 

Slope

-1.11

-0.78

-1.06

-0.458

-1.59

-2.57

 

P value

0.011a

0.015a

0.040a

0.039a

0.015a

0.007a

  1. Composition is presented in nanomoles per milligram of tissue wet weight. aDenotes significant value. Ala, alanine; Asx, asparagine + aspartate; Glx, glutamate + glutamine; Ile, isoleucine; Leu, leucine; OA, osteoarthritic; Ser, serine.