Skip to main content

Advertisement

Table 2 Crude and adjusted baseline characteristics of rheumatoid arthritis patients and controlsa

From: Coronary arterial calcification in rheumatoid arthritis: comparison with the Multi-Ethnic Study of Atherosclerosis

  Unadjusted Adjusted
  RA (n = 195) MESA (n = 1,073) P value RA (n = 195) MESA (n = 1,073) Adjusted % difference P value
Demographics        
   Age (years) 59 ± 9 64 ± 10 <0.001 - - - -
   Female 118 (60.5) 526 (49.0) 0.003 - - - -
   Race        
Caucasian 169 (85.8) 540 (50.3) <0.001 - - - -
African American 16 (8.2) 533 (49.7)      
Other 10 (5.1) 0 (0)      
   Education        
Some college or higher 147 (75.4) 741 (71.5) 0.26 69.9 73.6 -5.0 0.34
Cardiovascular risk factors        
   Diabetes 11 (5.6) 142 (13.2) 0.003 8.1 11.1 -27.0 0.29
   Fasting glucose (mg/dl) 93 ± 21 105 ± 31 <0.001 95.9 103.8 -8.2 0.001
   Hypertension        
Presentb 105 (53.6) 597 (55.6) 0.59 64.3 54.3 +18.4 0.018
Systolic blood pressure (mmHg) 128 ± 19 128 ± 21 0.93 132 125 +5.6 0.002
Diastolic blood pressure (mmHg) 76 ± 9 72 ± 10 <0.001 77.1 71.5 +7.8 <0.001
Antihypertensive use 79 (40.5) 428 (39.9) 0.87 53.0 36.4 +45.6 <0.001
   Lipids        
Total cholesterol (mg/dl) 195 ± 38 197 ± 38 0.62 194 197 -1.5 0.41
LDL cholesterol (mg/dl) 116 ± 31 117 ± 32 0.53 115.2 117.6 -2.1 0.34
HDL cholesterol (mg/dl) 55 ± 19 52 ± 15 0.03 54.4 51.6 +5.4 0.020
Triglycerides (mg/dl) 126 ± 93 118 ± 72 0.25 101.2 103.8 -2.5 0.53
Lipid medication use 34 (17.4) 231 (21.5) 0.20 16.2 21.6 -25.0 0.10
   Cigarette smoking        
Current 23 (11.8) 152 (14.4) 0.33 10.1 12.9 -21.7 0.30
Ever 115 (59.0) 591 (56.9) 0.60 59.2 57.4 +3.1 0.67
   Body mass index (kg/m2) 28.4 ± 5.3 29.3 ± 5.7 0.034 28.8 29.3 -1.7 0.25
   Waist circumference (cm) 95.7 ± 15.5 99.5 ± 14.7 0.002 96.9 99.3 -2.4 0.050
   Any physical activity 144 (73.9)) 832 (78.5 0.15 70.6 80.0 -11.8 0.010
   Homocysteine (μmol/l) 9.45 ± 2.80 9.28 ± 3.23 0.45 9.49 8.88 +6.9 0.003
   Serum inflammatory markers        
C-reactive protein (mg/l) 2.5 (1.1 to 7.2) 2.2 (1.0 to 4.7) 0.03 3.0 2.1 +44.0 <0.001
IL-6 (pg/ml) 3.9 (1.8 to 7.8) 1.3 (0.8 to 2.0) <0.001 4.0 1.3 +208 <0.001
Fibrinogen (mg/dl) 335(278 to 416) 340 (294 to 390) 0.98 358 338 +5.9 0.001
sICAM-1 (ng/ml) 299(229 to 371) 261 (219 to 307) <0.001 293 259 +13.1 <0.001
E-selectin (ng/ml) 49 (30 to 73) 50 (40 to 63) 0.46 50 49 +1.4 0.85
Composite risk factors        
   Framingham 10-year riskc (%) 7 ± 7 8 ± 7 0.04 9.35 8.25 +13.3 0.006
   Reynolds Risk Score (women only) (%) 1.0 (0 to 2.0) 1.4 (0.2 to 2.7) 0.001 1.50 1.42 +5.6 0.60
   Metabolic syndrome (Adult Treatment Panel III) 44 (22.6) 368 (34.5) <0.001 24.4 34.0 -28.2 0.016
  1. aEvaluation of Subclinical Cardiovascular Disease and Predictors of Events in Rheumatoid Arthritis (ESCAPE RA) study. Adjusted for age, gender and race. Characteristics expressed as the mean ± standard deviation, as n (%) or as the median (interquartile range). HDL, high-density lipoprotein; LDL, low-density lipoprotein; MESA. Multi-Ethnic Study of Atherosclerosis; RA. rheumatoid arthritis; sICAM-1, soluble intracellular adhesion molecule 1. bPresence of hypertension defined as resting blood pressure >140/90 mmHg or use of antihypertensive medication. cNational Cholesterol Education Program criteria; excluding diabetics (fasting glucose ≥ 126 or use of diabetes medication).