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Table 4 Crude and adjusted associations of rheumatoid arthritis status with mean Agatston scoresa

From: Coronary arterial calcification in rheumatoid arthritis: comparison with the Multi-Ethnic Study of Atherosclerosis

  Model 1 Model 2 Model 3 Model 4b
Characteristic β (95% CI) β (95% CI) β (95% CI) β (95% CI)
RA vs. MESAc 32.6* (2.04 to 64.1) 44.4* (12.3 to 76.4) 53.1* (19.8 to 86.4) 43.8* (4.9 to 82.8)
  Crude Mean (95% CI) Adjusted Mean (95% CI) Adjusted Mean (95% CI) Adjusted Mean (95% CI)
RA CAC scored 145 (116 to 174) 162 (133 to 191) 175 (144 to 205) 166 (131 to 200)
MESA CAC scored 112 (100 to 125) 118 (105 to 130) 122 (109 to 134) 122 (109 to 135)
  1. aAssociations in subjects with prevalent coronary calcification in the Evaluation of Subclinical Cardiovascular Disease and Predictors of Events in Rheumatoid Arthritis study. Analyses include 667 subjects with Agatston coronary artery calcification (CAC) score > 0 and complete data. Model 1, crude model, no adjustment; model 2, adjusted for sociodemographics (age, gender, African American race, highest educational level attained); model 3, adjusted for model 2 covariates + cardiovascular risk factors (hypertension, diabetes, smoking, high-density lipoprotein-cholesterol and low-density lipoprotein-cholesterol, and lipid lowering medication use); model 4, adjusted for model 3 covariates + log IL-6. bAdditional covariates tested but noncontributory to the model: log C-reactive protein, log fibrinogen, log soluble intracellular adhesion molecule, log homocysteine, exercise, body mass index, and waist circumference. c β coefficients (95% confidence intervals) representing the difference in mean Agatston CAC score for rheumatoid arthritis (RA) participants vs. Multi-Ethnic Study of Atherosclerosis (MESA) controls from robust regression models. * β coefficient significant at P < 0.05.dValues represent crude (model 1) and adjusted (models 2 to 4) mean (95% confidence interval) coronary artery calcification scores per group (RA or MESA) under the robust regression model above.