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Table 5 Linear regression analysis of sRAGE levels among 138 patients with established rheumatoid arthritis (RA)

From: Serum levels of soluble receptor for advanced glycation end products and of S100 proteins are associated with inflammatory, autoantibody, and classical risk markers of joint and vascular damage in rheumatoid arthritis

Variable

β

SE

t

Pvalue

95% Confidence interval

Univariate analysis:

     

   RF

-0.23

0.09

-2.56

0.01

-0.41 to -0.05

   Current smoker

-0.24

0.11

-2.14

0.03

-0.47 to -0.02

   Serum creatininea

0.23

0.13

1.77

0.08

-0.03 to 0.49

   History of vasculitis

-0.29

0.14

-2.07

0.04

-0.57 to -0.01

   Family history CVD

-0.20

0.10

-2.03

0.04

-0.39 to -0.005

   HDLa

-0.30

0.17

-1.77

0.08

-0.64 to 0.04

   CRPa

-0.13

0.05

-2.59

0.01

-0.23 to -0.03

   Diastolic blood pressure

-0.01

0.004

-2.73

0.007

-0.02 to -0.003

   Carriage of RAGE 82S

-0.32

0.10

-3.06

0.003

-0.53 to -0.11

   S100A8a

-0.06

0.03

-2.51

0.01

-0.11 to -0.01

   S100A9a

-0.08

0.04

-1.94

0.06

-0.15 to 0.002

   S100A12a

-0.08

0.05

-1.70

0.09

-0.18 to 0.01

Multivariate analysis:

     

   Carriage of RAGE 82S

-0.33

0.12

-2.88

0.005

-0.56 to -0.10

   HDLa

-0.35

0.16

-2.13

0.04

-0.68 to -0.02

   CRPa

-0.14

0.05

-2.63

0.01

-0.24 to -0.03

   History of vasculitis

-0.41

0.15

-2.68

0.009

-0.71 to -0.10

  1. Variables that were not listed in the simple linear regression model did not achieve P < 0.1. The selected covariates from simple linear regression (P < 0.1) of current smoker, RF, family history of CVD, diastolic blood pressure, creatinine, S100A8 and S100A12 levels were removed from the multiple linear regression model because these covariates did not independently correlate with the dependent variable. R2 of the multiple linear regression model = 0.24. Adjusted R2 = 0.1
  2. aLogarithmic base e transformation; sRAGE was logarithmically (base e) transformed.
  3. CRP, C-reactive protein; CVD, cardiovascular disease; HDL, high-density lipoprotein; RAGE, receptor for advanced glycation end products; RF, rheumatoid factor.