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Table 2 Distribution of estimated haplotype frequencies in the TNFAIP3 locus

From: Analysis of TNFAIP3, a feedback inhibitor of nuclear factor-κB and the neighbor intergenic 6q23 region in rheumatoid arthritis susceptibility

Haplotype #

rs600144

rs11970361

rs11970411

rs582757

rs17780429

Controls (n [%])

Cases (n [%])

OR (95% CI)

1

T

C

G

C

A

427 (13.2%)

399 (12.1%)

0.92 (0.79 to 1.06)

2

T

T

C

T

G

185 (5.7%)

175 (5.3%)

0.93 (0.76 to 1.16)

3

T

C

G

C

G

443 (13.7%)

420 (12.7%)

0.93 (0.81 to 1.07)

4

C

C

G

T

G

849 (26.2%)

843 (25.5%)

0.98 (0.88 to 1.09)

5

T

C

G

T

G

1,159 (35.8%)

1,271 (38.5%)

1.14 (1.03 to 1.26)

6

T

C

C

T

G

141 (4.4%)

162 (4.9%)

1.15 (0.91 to 1.44)

  1. Distribution of estimated haplotype frequencies in the TNFAIP3 locus for control individuals (controls) and patients with rheumatoid arthritis (cases). The minor allele of each tag-single nucleotide polymorphism is presented in bold. Haplotypes with frequency over 2% are shown, ordered by the odds ratio (OR) comparing cases with controls. Haplotype #5 was significantly different. CI, confidence interval.