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Table 4 Allele frequency differences in tagSNPs of the intergenic 6q23 region: ACPA-positive cases versus controls

From: Analysis of TNFAIP3, a feedback inhibitor of nuclear factor-κB and the neighbor intergenic 6q23 region in rheumatoid arthritis susceptibility

SNP

MAF% (n/N)

OR (95%CI)

P

rs566097

   

   ACPA+ cases

10.9 (84/772)

0.94 (0.7 to 1.2)

NS

   Controls

11.5 (367/3,190)

  

rs13207033

   

   ACPA+ cases

25.1 (185/736)

0.80 (0.66 to 0.96)

0.015

   Controls

29.7 (914/3,082)

  

rs489738

   

   ACPA+ cases

18.2 (138/760)

0.97 (0.8 to 1.2)

NS

   Controls

18.6 (586/3,158)

  

rs12194935

   

   ACPA+ cases

26.1 (198/758)

1.18 (1.0 to 1.4)

NS

   Controls

23.0 (726/3,154)

  

rs536331

   

   ACPA+ cases

37.9 (292/770)

0.83 (0.71 to 0.97)

0.023

   Controls

42.4 (1,351/3,184)

  

rs675520

   

   ACPA+ cases

44.5 (334/750)

0.82 (0.70 to 0.96)

0.014

   Controls

49.5 (1,520/3,070)

  

rs6920220

   

   ACPA+ cases

22.3 (172/770)

1.15 (0.95 to 1.39)

NS

   Controls

20.1 (639/3,184)

  

rs694069

   

   ACPA+ cases

35.5 (273/770)

0.82 (0.70 to 0.97)

0.019

   Controls

40.1 (1,276/3,186)

  

rs6917441

   

   ACPA+ cases

27.9 (212/760)

1.11 (0.9 to 1.3)

NS

   Controls

25.8 (816/3,166)

  

rs647108

   

   ACPA+ cases

41.9 (321/766)

1.04 (0.9 to 1.2)

NS

   Controls

41.0 (1,306/3,184)

  
  1. Allele frequency differences in tag-single nucleotide polymorphism (SNP) of the intergenic 6q23 region between patients with rheumatoid arthritis positive for anti-citrullinated peptide antibodies (ACPA+ cases) and control individuals (controls). MAF, minor allele frequency; n, number of minor alleles; N, total number of alleles.