From: Developments in the scientific understanding of osteoarthritis
Tissue | Molecule | Markers of synthesis | Markers of degradation | BIPED classification |
---|---|---|---|---|
Bone | Type I collagen | Â | PYDa | B |
 |  |  | NTX-Ia,b | D |
 |  |  | CTX-Ia,b | P |
 | Noncollagenous proteins | Osteocalcinb |  | P |
Cartilage | Type II collagen | PIIANPb | Â | P |
 |  | Total PIINP |  | D |
 |  | PIICPb,c |  | D, P |
 |  |  | CTX-IIa,c | D, B, P, E |
 |  |  | HELIX-IIa | P |
 |  |  | Coll 2-1a,b | P |
 |  |  | Coll 2-1 NO2a,b | P |
 |  |  | C2Ca,b | P, E |
 |  |  | 1,2Ca,b | P, E |
 | Aggrecan | Epitope 846 (cartilage contentc) |  | E |
 | Nonaggrecan and noncollagenous proteins |  | COMPb,c | D, B, P |
 |  |  | Pentosidinea,b | P |
 | Proteases and their inhibitors |  | MMPsb | B, P, E |
 |  |  | TIMPsb | B, P |
Synovium | Type III collagen | Â | GIc-GaI-PYDa | E |
 | Noncolagenous proteins | YKL-40b,c |  | B, E |
 |  | Hayluronic acidb |  | B, P |