|
Tissue
|
Molecule
|
Markers of synthesis
|
Markers of degradation
|
BIPED classification
|
|---|
|
Bone
|
Type I collagen
| |
PYDa
|
B
|
| | | |
NTX-Ia,b
|
D
|
| | | |
CTX-Ia,b
|
P
|
| |
Noncollagenous proteins
|
Osteocalcinb
| |
P
|
|
Cartilage
|
Type II collagen
|
PIIANPb
| |
P
|
| | |
Total PIINP
| |
D
|
| | |
PIICPb,c
| |
D, P
|
| | | |
CTX-IIa,c
|
D, B, P, E
|
| | | |
HELIX-IIa
|
P
|
| | | |
Coll 2-1a,b
|
P
|
| | | |
Coll 2-1 NO2a,b
|
P
|
| | | |
C2Ca,b
|
P, E
|
| | | |
1,2Ca,b
|
P, E
|
| |
Aggrecan
|
Epitope 846 (cartilage contentc)
| |
E
|
| |
Nonaggrecan and noncollagenous proteins
| |
COMPb,c
|
D, B, P
|
| | | |
Pentosidinea,b
|
P
|
| |
Proteases and their inhibitors
| |
MMPsb
|
B, P, E
|
| | | |
TIMPsb
|
B, P
|
|
Synovium
|
Type III collagen
| |
GIc-GaI-PYDa
|
E
|
| |
Noncolagenous proteins
|
YKL-40b,c
| |
B, E
|
| | |
Hayluronic acidb
| |
B, P
|
- aUrine. bSerum. c Synovial fluid. BIPED, B (burden of disease), I (investigative), P (prognostic), E (efficacy of intervention), D (diagnostic); C1,2C, assay that detects COL2-3/4C (short) epitope; C2C, assay that detects COL2-3/4C (long) epitope; Coll 2-1, 9-amino-acid peptide of type II collagen; Coll 2-1 NO2, nitrated form of Coll 2-1; COMP, cartilage oligomeric protein; CTX-I, carboxyl-terminal cross-linked telopeptide of type I collagen; CTX-II, C-terminal cross-linked telopeptide of type II collagen; Glc-Gal-PYD, glucosyl-galactosyl-pyridinoline; HELIX-II, helical type II collagen; MMP, matrix metalloproteinase; NTX-I, N-terminal cross-linked telopeptide of type I collagen; PIIANP, N-propeptide IIA of collagen type II; PIICP, C-propeptide of collagen type II; PIINP, N-propeptide II of collagen type II; PYD, pyridinoline; TIMP, tissue inhibitor of matrix metalloproteinase; YKL-40, cartilage glycoprotein 39. Reproduced with permission from Rouseeau and Delmas [80].
