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Figure 3 | Arthritis Research & Therapy

Figure 3

From: Candida albicansinduces cyclo-oxygenase 2 expression and prostaglandin E2 production in synovial fibroblasts through an extracellular-regulated kinase 1/2 dependent pathway

Figure 3

The effect of extracellular-regulated kinase (ERK) and nuclear factor κB (NFκB) inhibition on cyclo-oxygenase 2 (COX-2) production following infection of synovial fibroblasts with Candida albicans. Following infection of synovial fibroblasts for 12 h with 2 × 105 yeasts/dish in the absence or presence of (a) the mitogen-activated protein kinase (MEK)1/2 inhibitor U0126 or (b) the NFκB inhibitor MG-132 COX-2 protein levels were assessed by western blotting. Shown is a representative blots from N = 3 experiments. The graphs shows the results of densitometric analysis of bands expressed as the mean ± standard deviation (SD) of the relative fold change in band density with the ratio of the control condition normalized to 1 (N = 3, *, # P < 0.05).

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