Figure 1From: Anti-inflammatory and antiarthritic effects of piperine in human interleukin 1β-stimulated fibroblast-like synoviocytes and in rat arthritis modelsEffect of piperine on the production of proinflammatory mediators. (a) ELISA results show that piperine inhibited the production of interleukin (IL)6 and prostaglandin E2 (PGE2) in IL1β-stimulated fibroblast-like synoviocytes (FLSs) in a dose-dependent manner. (b) Piperine effects on IL6 and cyclo-oxygenase (COX)-2 mRNA expression measured by semiquantitative RT-PCR. (c) Piperine effects on COX-2 protein expression measured by western blot. Experiments were performed with synovial cells derived from patients with rheumatoid arthritis. Values are expressed ± standard error of the mea (SEM). ***P < 0.001 vs IL1β treated group without piperine.Back to article page