| Week 0 (mean ± SD) | Week 52 | Pvalue |
---|---|---|---|
Demographic details | Â | Â | Â |
Male:female | 19:12 | - | - |
Mean age (range, years) | 54 (23 to 78) | - | - |
Body mass index (range, kg/m2) | 28 (17 to 45) | - | - |
Rheumatoid arthritis characteristics | Â | Â | Â |
Disease duration, mean (range, months) | 1.8 (1 to 12) | - | - |
Tender joint count (out of 53) | 18 (14) | 7.6 (8.1) | < 0.001 |
Swollen joint count (out of 44) | 15 (8.9) | 5.0 (9.3) | < 0.001 |
Health assessment questionnaire score (maximum disability 24) | 3.3 (3.5) | 1.8 (2.7) | 0.006 |
Physician's global assessment of disease activity (maximum 100) | 37 (27) | 26 (28) | 0.013 |
Joint pain (VAS, maximum 100) | 51 (32) | 24 (26) | < 0.001 |
Rheumatoid factor level | 281 (438) | 98 (127) | 0.011 |
Disease activity score, 4 v | 4.3 (1.6) | 2.6 (1.4) | < 0.001 |
Rheumatoid factor positive, n (%) | 21 (68%) | 17 (55%) | Â |
Cardiovascular risk factors | Â | Â | Â |
History of ever smoking, n (%) | 20 (65%) | - | - |
History of current smoking, n (%) | 8 (26%) | - | - |
History of hypertension, n (%) | 6 (19%) | - | - |
History of diabetes mellitus, n (%) | 3 (10%) | - | - |
History of hyperlipidaemia, n (%) | 2 (6.5%) | - | - |
History of myocardial infarction, n (%) | 1 (3.2%) | - | - |
History of angina, n (%) | 2 (6.5%) | - | - |
History of stroke and/or transient ischaemic attack, n (%) | 1 (3.2%) | - | - |
Family history of cardiovascular disease, n (%) | 6 (19%) | - | - |
Laboratory values | Â | Â | Â |
Erythrocyte sedimentation rate (mm/hour) | 40 (25) | 21 (16) | < 0.001 |
C-reactive protein (mg/L, normal < 6) | 27 (25) | 9.3 (12) | < 0.001 |