Relative risks for overall malignancies in RA patients versus general population. *Excluding nonmelanoma skin. †All solid tumors. ‡Excluding lymphatic and hematopoietic. CI, confidence interval; DMARD, disease-modifying antirheumatic drug; MTX, methotrexate; n, number of malignancies; N, population size; SIR, standardized incidence ratio; TNF, tumor necrosis factor. For original references see Smitten and coworkers .