|
Cartilage region
|
Number
|
IsoAsp μM/g cartilage ± SEM
|
Protein μg/g cartilage ± SEM
|
GAG μg/g cartilage ± SEM
|
|---|
|
Normal
|
8
|
7,092 ± 1,568
|
65,092 ± 18,017
|
743 ± 102
|
|
Lesioned OA
|
14
|
4,942 ± 719
|
15,281 ± 552a
|
4,463 ± 1,053b
|
|
Non-lesioned OA
|
14
|
7,439 ± 1,273
|
17,926 ± 1,134c
|
2,911 ± 657b
|
|
Superficial
|
6
|
2,453 ± 315c
|
11,266 ± 818c
|
3,626 ± 921
|
|
Deep
|
6
|
3,999 ± 665d
|
16,894 ± 3,105c
|
7,316 ± 1,279a, d, e
|
- aP < 0.001 compared to normal cartilage; bP < 0.01 compared to normal cartilage; cP < 0.05 compared to normal cartilage; dP < 0.05 compared to superficial cartilage; eP < 0.05 compared to osteoarthritis (OA) lesion cartilage. GAG, glycosaminoglycan; IsoAsp, isomerized aspartate; SEM, standard error of the mean.
