Figure 3
Examples of temporal changes in expression levels of selected genes associated with each of the four sets of genes identified by cluster analysis. Genes include those present in metabolite transport (a) and voltage-gate channels (b) of cluster 1, apoptosis (c) and adhesion (d) of cluster 2, adhesion (e) and fatty acid and lipid metabolism (f) of cluster 3, immunity (g), and muscle cell contraction (h). Each gene profile is presented as a pair-wise comparison of expressions in the salivary glands of C57BL/6.NOD-Aec1Aec2 mice at 8, 12, 16, and 20 weeks of age relative to 4 weeks of age. Aec, autoimmunexocrinopathy; NOD, non-obese diabetic.