Figure 2From: Gene expression profiling in the synovium identifies a predictive signature of absence of response to adalimumab therapy in rheumatoid arthritisChanges in immunohistochemistry parameters in the synovial biopsies of severe rheumatoid arthritis patients. Biopsies were collected prior to (T0) (n = 25) and 12 weeks after (T12) (n = 25) initiation of adalimumab therapy. (a) Characteristic images of the stained markers (sublining C68, CD3, CD20, and CD15) (original magnification × 400). (b) Ratio of surface staining to staining of the nuclei (S/N). Slides stained for CD68, CD3, CD15, and CD20 were analyzed using ImageJ with six digitalized pictures (magnification × 400) obtained for each sample. Open boxes refer to all patients, and closed boxes refer to responders. Results are the mean and standard error of the mean of S/N ratio. *P < 0.05; **P < 0.005 versus good and moderate responders using Wilcoxon matched-pairs signed rank tests.Back to article page