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Table 1 Human interleukin-17 and interleukin-17 receptor family

From: The biological and clinical importance of the 'new generation' cytokines in rheumatic diseases

Ligands (alternative names)

Produced mainly by

Binding receptors

Tissue expression of receptors

IL-17 (IL-17A)

T cells (Th17)

IL-17RA

Widely expressed

  

IL-17RC

Cartilage, synovial tissue, brain, heart, small intestine, kidney, lung, colon, liver, skeletal muscle, placenta, prostate, low expression in thymus

IL-17A/IL-17F

T cells (Th17)

IL-17RA

 
  

IL-17RC

 

IL-17B

Adult pancreas, small intestine, stomach

IL-17RB

Several endocrine tissues, liver, kidney, pancreas, testis, brain, colon, small intestine, not detected in lymphoid organs and peripheral leucocytes

IL-17C

Prostate, foetal kidney

Unknown

 

IL-17D

Adipose tissue, skeletal muscle, CNS

Unknown

 

IL-17E (IL-25)

CNS, kidney, lung, prostate, testis, adrenal gland, trachea

IL-17RA

 
  

IL-17RB

 

IL-17F

T cells (Th17)

IL-17RA

 
  

IL-17RC

 

Unknown

 

IL-17RD (SEF homologue)

Endothelial cells, kidney, colon, skeletal muscle, heart, salivary glands, seminal vesicles, small intestine

Unknown

 

IL-17RE

Tumour cell lines

  1. CNS, central nervous system; IL, interleukin; SEF, similar expression to fibroblast growth factors.