From: The biological and clinical importance of the 'new generation' cytokines in rheumatic diseases
Ligands (alternative names) | Produced mainly by | Binding receptors | Tissue expression of receptors |
---|---|---|---|
IL-17 (IL-17A) | T cells (Th17) | IL-17RA | Widely expressed |
 |  | IL-17RC | Cartilage, synovial tissue, brain, heart, small intestine, kidney, lung, colon, liver, skeletal muscle, placenta, prostate, low expression in thymus |
IL-17A/IL-17F | T cells (Th17) | IL-17RA | Â |
 |  | IL-17RC |  |
IL-17B | Adult pancreas, small intestine, stomach | IL-17RB | Several endocrine tissues, liver, kidney, pancreas, testis, brain, colon, small intestine, not detected in lymphoid organs and peripheral leucocytes |
IL-17C | Prostate, foetal kidney | Unknown | Â |
IL-17D | Adipose tissue, skeletal muscle, CNS | Unknown | Â |
IL-17E (IL-25) | CNS, kidney, lung, prostate, testis, adrenal gland, trachea | IL-17RA | Â |
 |  | IL-17RB |  |
IL-17F | T cells (Th17) | IL-17RA | Â |
 |  | IL-17RC |  |
Unknown | Â | IL-17RD (SEF homologue) | Endothelial cells, kidney, colon, skeletal muscle, heart, salivary glands, seminal vesicles, small intestine |
Unknown | Â | IL-17RE | Tumour cell lines |