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Table 1 Human interleukin-17 and interleukin-17 receptor family

From: The biological and clinical importance of the 'new generation' cytokines in rheumatic diseases

Ligands (alternative names) Produced mainly by Binding receptors Tissue expression of receptors
IL-17 (IL-17A) T cells (Th17) IL-17RA Widely expressed
   IL-17RC Cartilage, synovial tissue, brain, heart, small intestine, kidney, lung, colon, liver, skeletal muscle, placenta, prostate, low expression in thymus
IL-17A/IL-17F T cells (Th17) IL-17RA  
   IL-17RC  
IL-17B Adult pancreas, small intestine, stomach IL-17RB Several endocrine tissues, liver, kidney, pancreas, testis, brain, colon, small intestine, not detected in lymphoid organs and peripheral leucocytes
IL-17C Prostate, foetal kidney Unknown  
IL-17D Adipose tissue, skeletal muscle, CNS Unknown  
IL-17E (IL-25) CNS, kidney, lung, prostate, testis, adrenal gland, trachea IL-17RA  
   IL-17RB  
IL-17F T cells (Th17) IL-17RA  
   IL-17RC  
Unknown   IL-17RD (SEF homologue) Endothelial cells, kidney, colon, skeletal muscle, heart, salivary glands, seminal vesicles, small intestine
Unknown   IL-17RE Tumour cell lines
  1. CNS, central nervous system; IL, interleukin; SEF, similar expression to fibroblast growth factors.