From: The biological and clinical importance of the 'new generation' cytokines in rheumatic diseases
 | In vitro | In vivo |
---|---|---|
Inflammation | Neutrophilic response | IL-17-deficient mice |
 |    Stimulation of G-CSF production |    Attenuated form of CIA |
 |    Stimulation of CXCL1, Groα (mouse) |    Protected from arthritis in IL-1Ra-deficient mice |
 |    CXCL8 (human) |    No effect in PIA |
 | T-cell and DC recruitment |  |
 |    CCL20 production |  |
 | IL-1 and TNF-α production by macrophages |  |
 | IL-6, PGE2 production by synovial fibroblasts |  |
 | NO in articular chondrocytes |  |
Tissue destruction | Production of MMPs | Intra-articular IL-17 induces cartilage degradation |
 |  | Local IL-17 gene transfer induces MMPs and high RANKL/OPG ratio and osteoclastogenesis |
 |  | Joint destruction is dependent on IL-17R signalling in radiation-resistant cells in SCW arthritis |