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Table 2 Effect of interleukin-17 in arthritis

From: The biological and clinical importance of the 'new generation' cytokines in rheumatic diseases

 

In vitro

In vivo

Inflammation

Neutrophilic response

IL-17-deficient mice

 

   Stimulation of G-CSF production

   Attenuated form of CIA

 

   Stimulation of CXCL1, Groα (mouse)

   Protected from arthritis in IL-1Ra-deficient mice

 

   CXCL8 (human)

   No effect in PIA

 

T-cell and DC recruitment

 
 

   CCL20 production

 
 

IL-1 and TNF-α production by macrophages

 
 

IL-6, PGE2 production by synovial fibroblasts

 
 

NO in articular chondrocytes

 

Tissue destruction

Production of MMPs

Intra-articular IL-17 induces cartilage degradation

  

Local IL-17 gene transfer induces MMPs and high RANKL/OPG ratio and osteoclastogenesis

  

Joint destruction is dependent on IL-17R signalling in radiation-resistant cells in SCW arthritis

  1. CIA, collagen-induced arthritis; DC, dendritic cell; G-CSF, granulocyte colony-stimulating factor; IL, interleukin; IL-1Ra, interleukin-1 receptor antagonist; MMP, matrix metalloproteinase; NO, nitric oxide; OPG, osteoprotegerin; PGE2, prostaglandin E2; PIA, proteoglycan-induced arthritis; RANKL, receptor activator of nuclear factor-kappa-B ligand; SCW, streptococcal cell wall-induced; TNF-α, tumour necrosis factor-alpha.