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Table 2 Effect of interleukin-17 in arthritis

From: The biological and clinical importance of the 'new generation' cytokines in rheumatic diseases

  In vitro In vivo
Inflammation Neutrophilic response IL-17-deficient mice
     Stimulation of G-CSF production    Attenuated form of CIA
     Stimulation of CXCL1, Groα (mouse)    Protected from arthritis in IL-1Ra-deficient mice
     CXCL8 (human)    No effect in PIA
  T-cell and DC recruitment  
     CCL20 production  
  IL-1 and TNF-α production by macrophages  
  IL-6, PGE2 production by synovial fibroblasts  
  NO in articular chondrocytes  
Tissue destruction Production of MMPs Intra-articular IL-17 induces cartilage degradation
   Local IL-17 gene transfer induces MMPs and high RANKL/OPG ratio and osteoclastogenesis
   Joint destruction is dependent on IL-17R signalling in radiation-resistant cells in SCW arthritis
  1. CIA, collagen-induced arthritis; DC, dendritic cell; G-CSF, granulocyte colony-stimulating factor; IL, interleukin; IL-1Ra, interleukin-1 receptor antagonist; MMP, matrix metalloproteinase; NO, nitric oxide; OPG, osteoprotegerin; PGE2, prostaglandin E2; PIA, proteoglycan-induced arthritis; RANKL, receptor activator of nuclear factor-kappa-B ligand; SCW, streptococcal cell wall-induced; TNF-α, tumour necrosis factor-alpha.