Skip to main content
Figure 1 | Arthritis Research & Therapy

Figure 1

From: Apigenin, a non-mutagenic dietary flavonoid, suppresses lupus by inhibiting autoantigen presentation for expansion of autoreactive Th1 and Th17 cells

Figure 1

Apigenin suppressed nucleosome-specific interferon-gamma (IFN-γ) response and IgG-autoantibody production. Splenocytes from 5- to 6-month-old unmanipulated SNF1 mice were stimulated with nucleosomes in the presence of various amounts of apigenin or vehicle (dimethyl sulfoxide-phosphate-buffered saline). (a) Apigenin markedly suppressed IFN-γ responses by nucleosome-specific T cells in enzyme-linked immunosorbent spot assay. (b) Apigenin significantly reduced the level of IgG class autoantibodies in nucleosome-stimulated lupus Th cell-B cell coculture assays. *P < 0.001, **P < 0.01, and xP < 0.02. dsDNA, double-stranded DNA; SNF1, (SWR × NZB)F1; ssDNA, single-stranded DNA.

Back to article page

Arthritis Research & Therapy

ISSN: 1478-6362

Contact us