Association of MICA with rheumatoid arthritis independent of known HLA-DRB1risk alleles in a family-based and a case control study

Table 1 Association of MICA polymorphisms within the first French Caucasian family cohort

	MICA-210					MICA-250	MICA-300
(a) French population 1 – all individuals without controlling for LD with HLA-DRB1
Minor allele	4	5	5.1	6	9	A	A
Frequency in cases/controls^a	7%/12%	12%/7%	42%/36%	26%/25%	13%/20%	23%/34%	8%/4%
Minor allele transmitted/untransmitted	13/21	21/13	44/36	35/33	17/29	26/48	15/7
Transmission rate	38%	62%	55%	51%	37%	35%	68%
TDT P value	0.172	0.172	0.376	0.815	0.080	0.011	0.091
(b) French population 1, subgroup without HLA-DRB1 risk alleles
Minor allele transmitted/untransmitted	5/10	5/4	18/15	18/12	5/10	6/18	3/1
Transmission rate	33%	56%	55%	60%	33%	25%	75%
TDT P value	0.200	0.740	0.600	0.270	0.200	0.014	0.317
(c) French population 1, all individuals, controlling for LD with HLA-DRB1 by conditional logistic regression
OR (95% CI)^b	0.59 (0.25–1.34)	1.48 (0.64–3.54)	1.28 (0.77–2.16)	1.23 (0.71–2.17)	0.51 (0.24–1.05)	0.46 (0.25–0.82)	1.2 (0.37–4.15)
P value	0.235	0.428	0.379	0.518	0.072	0.007^d	0.944
LRT^c P value	0.165	0.319	0.314	0.433	0.048	0.005^d	0.728

^aControls are non-transmitted alleles; ^bodds ratio of transmission of minor allele versus transmission of major allele as determined in logistic regression; ^clikelihood ratio test evaluating model including HLA-DRB1 alleles S2 and S3P and MICA-250 versus S2 and S3P only. For the HLA-DRB1 locus, allele L was used as reference. ^dP value corrected for multiple testing less than 0.05. CI, confidence interval; LD, linkage disequilibrium; TDT, transmission disequilibrium test.

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