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Table 1 Association of MICA polymorphisms within the first French Caucasian family cohort

From: Association of MICA with rheumatoid arthritis independent of known HLA-DRB1risk alleles in a family-based and a case control study

  MICA-210 MICA-250 MICA-300
(a) French population 1 – all individuals without controlling for LD with HLA-DRB1        
   Minor allele 4 5 5.1 6 9 A A
   Frequency in cases/controlsa 7%/12% 12%/7% 42%/36% 26%/25% 13%/20% 23%/34% 8%/4%
   Minor allele transmitted/untransmitted 13/21 21/13 44/36 35/33 17/29 26/48 15/7
   Transmission rate 38% 62% 55% 51% 37% 35% 68%
   TDT P value 0.172 0.172 0.376 0.815 0.080 0.011 0.091
(b) French population 1, subgroup without HLA-DRB1 risk alleles        
   Minor allele transmitted/untransmitted 5/10 5/4 18/15 18/12 5/10 6/18 3/1
   Transmission rate 33% 56% 55% 60% 33% 25% 75%
   TDT P value 0.200 0.740 0.600 0.270 0.200 0.014 0.317
(c) French population 1, all individuals, controlling for LD with HLA-DRB1 by conditional logistic regression        
   OR (95% CI)b 0.59
(0.25–1.34)
1.48
(0.64–3.54)
1.28
(0.77–2.16)
1.23
(0.71–2.17)
0.51
(0.24–1.05)
0.46
(0.25–0.82)
1.2
(0.37–4.15)
   P value 0.235 0.428 0.379 0.518 0.072 0.007d 0.944
   LRTc P value 0.165 0.319 0.314 0.433 0.048 0.005d 0.728
  1. aControls are non-transmitted alleles; bodds ratio of transmission of minor allele versus transmission of major allele as determined in logistic regression; clikelihood ratio test evaluating model including HLA-DRB1 alleles S2 and S3P and MICA-250 versus S2 and S3P only. For the HLA-DRB1 locus, allele L was used as reference. dP value corrected for multiple testing less than 0.05. CI, confidence interval; LD, linkage disequilibrium; TDT, transmission disequilibrium test.