Table 3 Case-control analysis in German Caucasians
(a) All individuals without controlling for LD with HLA-DRB1 | |
|---|---|
Minor allele | 250A |
Allele frequency in cases/controls | 22%/33% |
Total alleles of RA cases/controls | 178/368 |
OR (95% CI) | 0.60 (0.4–0.9) |
OR P value | 0.016 |
(b) Subgroup without HLA-DRB1 risk alleles | |
Frequency in cases/controls | 14%/34% |
Total alleles of RA cases/controls | 50/216 |
OR (95% CI) | 0.31 (0.1–0.7) |
OR P value | 0.005 |
(c) All individuals, controlling for LD with HLA-DRB1 by logistic regression | |
OR (95% CI) | 0.6 (0.37–0.96) |
P value | 0.032 |
LRTa P value | 0.022 |