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Table 3 Case-control analysis in German Caucasians

From: Association of MICA with rheumatoid arthritis independent of known HLA-DRB1risk alleles in a family-based and a case control study

(a) All individuals without controlling for LD with HLA-DRB1  
   Minor allele 250A
   Allele frequency in cases/controls 22%/33%
   Total alleles of RA cases/controls 178/368
   OR (95% CI) 0.60 (0.4–0.9)
   OR P value 0.016
(b) Subgroup without HLA-DRB1 risk alleles  
   Frequency in cases/controls 14%/34%
   Total alleles of RA cases/controls 50/216
   OR (95% CI) 0.31 (0.1–0.7)
   OR P value 0.005
(c) All individuals, controlling for LD with HLA-DRB1 by logistic regression  
   OR (95% CI) 0.6 (0.37–0.96)
   P value 0.032
   LRTa P value 0.022
  1. aLikelihood ratio test evaluating model including HLA-DRB1 alleles S2 and S3P and MICA-250 versus S2 and S3P only. For the HLA-DRB1 locus, allele L was used as reference. CI, confidence interval; LD, linkage disequilibrium; OR, odds ratio; RA, rheumatoid arthritis.