Peripheral blood B-cell repletion. (a) Median numbers of CD19+ peripheral blood B cells in good responders (left) and non-responders or moderate responders (right) at different time points after B-cell depletion. Colours represent the median of different B-cell subsets: CD27-IgD+ naïve B cells are in light red, CD27+ IgD+ non-switched memory B cells (MemB) are in red, CD27-IgD- B cells are in light blue, and switched CD27+IgD- MemB are in blue. (b) Line diagram of switched MemB in good responders (continuous line) and in non-responders or moderate responders (dotted line). Mann-Whitney test for comparison of good responders versus other patients: *P < 0.05; **P < 0.01.