Table 1 Newly systemic lupus erythematosus-associated loci that were examined with previous evidence of association

ITGAM

16

Exon 3

rs1143679

G/A

1.78 (1.6 to 2.0)

Yes

3,818

European American

[7]

1.55 (1.2 to 2.0)

Yes

1,289

African American

[7]

2.07 (1.3 to 3.4)

Yes

271

Gullah

[7]

Other SNPs

Yes

[3, 4, 6]

STAT4

2

Intron 3

rs7574865

G/T

1.5 (1.2 to 1.8)

Yes

3,057

European

[3]

1.50 (1.4 to 1.7)

Yes

4,651

European American

[4]

1.55 (1.3 to 1.8)

Yes

2,287

European American

[8]

1.61 (1.4 to 1.9)

Yes

2,495

Japanese

[9]

1.62 (1.2 to 2.2)

Yes

565

Colombians

[10]

1.56 (1.4 to 1.7)

Yes

3,958

European

[12]

Other SNPs

Yes

[6, 11]

C8orf13-BLK

8

Intergenic

rs13277113

G/A

1.39 (1.3 to 1.5)

Yes

6,301

European American

[4]

Other SNPs

Yes

[3, 6]

TYK2

19

Exon 8

rs2304256

C/A

0.625 (0.5 to 0.8)

Yes

966

Swedish/Finnish

[15]

105:127^b

No

380^c

European/Indo-Pakistani

[16]

Other SNPs

No

[3]

MECP2

X

Intron 2

rs17435

A/T

1.58 (1.3 to 1.9)

Yes

1,364

Korean

[13]

1.29 (1.1 to 1.5)

Yes

2,160

European

[13]

1q25.1

1

Intergenic

rs10798269

G/A

0.82 (0.8 to 0.9)

Yes

6,728

European

[3]

BANK1

4

Intron 1

rs17266594

T/C

0.74 (0.6 to 0.9)

Yes

927

Scandinavian

[5]

0.70 (0.5 to 0.9)

Yes

576

German

[5]

0.63 (0.5 to 0.8)

Yes

450

Italian

[5]

0.78 (0.6 to 0.9)

Yes

1,136

Spanish

[5]

0.58 (0.4 to 0.8)

Yes

620

Argentinian

[5]

KIAA1542

11

Intron 4

rs4963128

G/A

0.78 (0.7 to 0.9)

Yes

6,728

European

[3]

PXK

3

Intron 5

rs6445975

T/G

1.25 (1.2 to 1.4)

Yes

6,728

European

[3]

LY9

1

Exon 8

rs509749

A/G

377:403^d

Yes

510^c

UK Caucasian

[14]

237:251^d

No

270^c

Canadian

[14]