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Table 1 Newly systemic lupus erythematosus-associated loci that were examined with previous evidence of association

From: Replication of recently identified systemic lupus erythematosus genetic associations: a case–control study

Locus Chr. Location SNP Allelesa OR (95% CI) Associated Sample size Population Reference
ITGAM 16 Exon 3 rs1143679 G/A 1.78 (1.6 to 2.0) Yes 3,818 European American [7]
      1.55 (1.2 to 2.0) Yes 1,289 African American [7]
      2.07 (1.3 to 3.4) Yes 271 Gullah [7]
    Other SNPs    Yes    [3, 4, 6]
STAT4 2 Intron 3 rs7574865 G/T 1.5 (1.2 to 1.8) Yes 3,057 European [3]
      1.50 (1.4 to 1.7) Yes 4,651 European American [4]
      1.55 (1.3 to 1.8) Yes 2,287 European American [8]
      1.61 (1.4 to 1.9) Yes 2,495 Japanese [9]
      1.62 (1.2 to 2.2) Yes 565 Colombians [10]
      1.56 (1.4 to 1.7) Yes 3,958 European [12]
    Other SNPs    Yes    [6, 11]
C8orf13-BLK 8 Intergenic rs13277113 G/A 1.39 (1.3 to 1.5) Yes 6,301 European American [4]
    Other SNPs    Yes    [3, 6]
TYK2 19 Exon 8 rs2304256 C/A 0.625 (0.5 to 0.8) Yes 966 Swedish/Finnish [15]
      105:127b No 380c European/Indo-Pakistani [16]
    Other SNPs    No    [3]
MECP2 X Intron 2 rs17435 A/T 1.58 (1.3 to 1.9) Yes 1,364 Korean [13]
      1.29 (1.1 to 1.5) Yes 2,160 European [13]
1q25.1 1 Intergenic rs10798269 G/A 0.82 (0.8 to 0.9) Yes 6,728 European [3]
BANK1 4 Intron 1 rs17266594 T/C 0.74 (0.6 to 0.9) Yes 927 Scandinavian [5]
      0.70 (0.5 to 0.9) Yes 576 German [5]
      0.63 (0.5 to 0.8) Yes 450 Italian [5]
      0.78 (0.6 to 0.9) Yes 1,136 Spanish [5]
      0.58 (0.4 to 0.8) Yes 620 Argentinian [5]
KIAA1542 11 Intron 4 rs4963128 G/A 0.78 (0.7 to 0.9) Yes 6,728 European [3]
PXK 3 Intron 5 rs6445975 T/G 1.25 (1.2 to 1.4) Yes 6,728 European [3]
LY9 1 Exon 8 rs509749 A/G 377:403d Yes 510c UK Caucasian [14]
      237:251d No 270c Canadian [14]
  1. Loci ordered as presented in Table 2. The SNPs selected for replication are detailed. Chr, chromosome; CI, confidence interval; OR, odds ratio. aMajor/minor alleles. bTransmitted:untransmitted. cNumber of families. dObserved:expected.