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Table 3 Combined analysis of allele frequency differences between SLE women and control women

From: Replication of recently identified systemic lupus erythematosus genetic associations: a case–control study

  Minor allele frequency (%)a Mantel – Haenszel analysis Breslow – Day test
SNP (locus) SLE cases Controls OR (95% CI) P value P value
rs1143679 (ITGAM) 22.3 (621/2,782) 15.1 (329/2,182) 1.67 (1.4 to 2.0) 2.0 × 10-11 0.6
rs7574865 (STAT4) 33.1 (636/1,920) 24.0 (317/1,322) 1.60 (1.4 to 1.9) 8.4 × 10-9 0.8
rs13277113 (C8orf13-BLK) 30.9 (777/2,514) 25.7 (475/1,848) 1.33 (1.2 to 1.5) 5.4 × 10-5 0.9
rs2304256 (TYK2) 22.9 (638/2,782) 27.2 (592/2,180) 0.81 (0.7 to 0.9) 0.0022 0.2
rs17435 (MECP2) 26.7 (744/2,784) 22.8 (498/2,186) 1.26 (1.1 to 1.4) 0.00085 0.7
rs10798269 (1q25.1) 27.1 (754/2,786) 32.3 (705/2,182) 0.77 (0.7 to 0.9) 6.2 × 10-5 0.4
rs17266594 (BANK1) 23.9 (464/1,938) 26.9 (386/1,436) 0.87 (0.7 to 1.0) 0.077 0.4
rs4963128 (KIAA1542) 30.4 (845/2,778) 33.9 (741/2,182) 0.85 (0.8 to 1.0) 0.011 0.2
rs6445975 (PXK) 26.7 (670/2,514) 23.5 (436/1,854) 1.22 (1.1 to 1.4) 0.0067 0.9
rs509749 (LY9) 43.3 (1,206/2,784) 44.0 (962/2,184) 0.98 (0.9 to 1.1) 0.7 0.5
  1. Loci ordered as presented in Table 2. All results refer to the minor allele of each SNP, which is indicated in Table 1. CI, confidence interval; OR, odds ratio; SLE, systemic lupus erythematosus. aData presented as percentage (number of minor alleles/total number of alleles).