Table 3 Combined analysis of allele frequency differences between SLE women and control women
Minor allele frequency (%)a | Mantel – Haenszel analysis | Breslow – Day test | |||
|---|---|---|---|---|---|
SNP (locus) | SLE cases | Controls | OR (95% CI) | P value | P value |
rs1143679 (ITGAM) | 22.3 (621/2,782) | 15.1 (329/2,182) | 1.67 (1.4 to 2.0) | 2.0 × 10-11 | 0.6 |
rs7574865 (STAT4) | 33.1 (636/1,920) | 24.0 (317/1,322) | 1.60 (1.4 to 1.9) | 8.4 × 10-9 | 0.8 |
rs13277113 (C8orf13-BLK) | 30.9 (777/2,514) | 25.7 (475/1,848) | 1.33 (1.2 to 1.5) | 5.4 × 10-5 | 0.9 |
rs2304256 (TYK2) | 22.9 (638/2,782) | 27.2 (592/2,180) | 0.81 (0.7 to 0.9) | 0.0022 | 0.2 |
rs17435 (MECP2) | 26.7 (744/2,784) | 22.8 (498/2,186) | 1.26 (1.1 to 1.4) | 0.00085 | 0.7 |
rs10798269 (1q25.1) | 27.1 (754/2,786) | 32.3 (705/2,182) | 0.77 (0.7 to 0.9) | 6.2 × 10-5 | 0.4 |
rs17266594 (BANK1) | 23.9 (464/1,938) | 26.9 (386/1,436) | 0.87 (0.7 to 1.0) | 0.077 | 0.4 |
rs4963128 (KIAA1542) | 30.4 (845/2,778) | 33.9 (741/2,182) | 0.85 (0.8 to 1.0) | 0.011 | 0.2 |
rs6445975 (PXK) | 26.7 (670/2,514) | 23.5 (436/1,854) | 1.22 (1.1 to 1.4) | 0.0067 | 0.9 |
rs509749 (LY9) | 43.3 (1,206/2,784) | 44.0 (962/2,184) | 0.98 (0.9 to 1.1) | 0.7 | 0.5 |