| |
RA case genotypesb
|
RA-free OA control genotypesb
|
|---|
|
HLA-DRB1 allelea
|
0
|
1
|
2
|
MAF
|
P (HWE)
|
0
|
1
|
2
|
MAF
|
P (HWE)
|
|---|
|
*01
|
350
|
139
|
7
|
0.154
|
0.121
|
223
|
75
|
1
|
0.129
|
0.040
|
|
*03
|
412
|
81
|
3
|
0.088
|
1
|
251
|
45
|
3
|
0.085
|
0.459
|
|
*04
|
268
|
192
|
36
|
0.266
|
0.819
|
234
|
64
|
1
|
0.110
|
0.229
|
|
*07
|
414
|
82
|
0
|
0.083
|
0.038
|
224
|
69
|
6
|
0.136
|
0.804
|
|
*08
|
471
|
25
|
0
|
0.025
|
1
|
279
|
20
|
0
|
0.033
|
1
|
|
*09
|
485
|
11
|
0
|
0.011
|
1
|
296
|
3
|
0
|
0.005
|
1
|
|
*10
|
466
|
30
|
0
|
0.030
|
1
|
294
|
5
|
0
|
0.008
|
1
|
|
*11
|
403
|
88
|
5
|
0.099
|
0.804
|
229
|
68
|
2
|
0.120
|
0.279
|
|
*12
|
486
|
10
|
0
|
0.010
|
1
|
282
|
17
|
0
|
0.028
|
1
|
|
*13
|
434
|
59
|
3
|
0.066
|
0.457
|
226
|
69
|
4
|
0.129
|
0.799
|
|
*14
|
475
|
21
|
0
|
0.021
|
1
|
283
|
15
|
1
|
0.028
|
0.209
|
|
*15
|
417
|
74
|
5
|
0.085
|
0.381
|
228
|
68
|
3
|
0.124
|
0.593
|
|
*16
|
435
|
60
|
1
|
0.063
|
0.711
|
262
|
36
|
1
|
0.064
|
1
|
- a Allele numbering according to Table S1 in Additional data file 1.
- b Numbers indicate counts of rare alleles.
- HWE = Hardy-Weinberg equilibrium; MAF = minor allele frequency; OA = osteoarthritis; RA = rheumatoid arthritis.
