Magnetically retainable microparticles for drug delivery to the joint: efficacy studies in an antigen-induced arthritis model in mice

Table 2 ^99mTc accumulation values obtained at day 4 when a magnet was implanted near the left knee

	mBSA + PBS	DXM suspension	Polymer microparticles	SPION suspension	Microparticles + SPIONs	Complete microparticles
	(+)	(+)	(+)	(+)	(+)	(+)
	1.95	0.86	1.98	1.7	2.17	1.29
	1.7	1.33	1.35	1.75	2.08	1.65
	1.55	1.08	1.61	1.89	2.17	1.43
	1.83	1.38	1.64	1.54	2.15	1.18
	2.12	1.39	1.86	1.44	2.22	1.54
Mean	1.83	1.21	1.69	1.66	2.16	1.42
SD	0.22	0.23	0.24	0.18	0.05	0.19

The values are expressed as the ratio of the gamma-counting values in the treated joint (left knee) to those of the untreated joint (right knee). (+) indicates groups with a magnet. DXM, dexamethasone 21-acetate; mBSA, methyl bovine serum albumin; PBS, phosphate-buffered saline; SD, standard deviation; SPION, superparamagnetic iron oxide nanoparticle.

ISSN: 1478-6362