Elevated pretreatment blood cytokines are associated with response to etanercept therapy. Logistic regression analysis was applied to cytokine measurements in 93 samples derived from three cohorts of etanercept new-start rheumatoid arthritis patients. Green circles, samples from the Japanese cohort; red circles, samples from the ABCoN cohort; blue circles, samples from the Swedish cohort; grey circles, the best-fit logistic regression curve; x values, actual cytokine concentrations; y values, an artificial noise value was added to achieve better visual separation of the actual cytokine values. P values are shown for each cytokine. The grey bar links the actual responder or nonresponder label of a sample with the logistic regression result of the same sample (probability of being a responder). For better readability, only six cytokines are shown. MCP-1, monocyte chemoattractant protein-1.