Prediction of responders and nonresponders. Calculations of classification errors for (a) the PAM training/cross-validation step on all cohorts combined, and (c) the PAM prediction steps for the three cohorts individually (top panel, ABCoN cohort; middle panel, Swedish cohort; bottom panel, Japanese cohort). R, responder; NR, nonresponder; NPV, negative predictive value; PPV, positive predictive value. (b) Complete biomarker of 24 discriminators listed according to rank order, with associated scores for nonresponders and responders in the right and far-right columns, respectively. ApoE, apolipoprotein E; COMP, cartilage oligomeric matrix protein; FGF-2, fibroblast growth factor-2; GM-CSF, granulocyte- macrophage colony-stimulating factor; IP-10, IFNγ-inducible protein 10; MCP-1, monocyte chemoattractant protein-1.