Table 1 Demographic, clinical and serologic characteristics of the three cohorts
Cohort | Parameter |
|---|---|
US-based (ABCoN) | Â |
   Age (years) | 50 (35 to 78) |
   Female sex | 23 (79) |
   CCP2 | 56.6 (1.2 to 500) |
   CRP (mg/l) | 60 (2 to 79) |
   ACR response < 20 | 15 (51.7) |
   ACR response > 50 | 14 (48.3) |
   Shared epitope present | 16/24 (66) |
   Disease duration (months) | 96 (12 to 396) |
Swedish | Â |
   Age (years) | 54 (32 to 77) |
   Female sex | 34 (79) |
   CCP2 | n.d. |
   CRP (mg/l) | 37.5 (10 to 166) |
   ACR response < 20 | 19 (44.2) |
   ACR response > 50 | 24 (55.8) |
   Shared epitope present | n.d. |
   Disease duration (months) | 108 (1 to 464) |
Japanese | Â |
   Age (years) | 56 (24 to 76) |
   Female sex | 20 (95%) |
   CCP2 | n.d. |
   Rheumatoid factor (units) | 66.9 (14.9 to 1,675) |
   CRP (mg/l) | 55 (33 to 75) |
   ACR response < 20 | 9/21 (29.0) |
   ACR response > 70 | 12/21 (38.7) |
   Shared epitope present | n.d. |
   Disease duration (months) | 151 (11 to 444) |