Higher potency of class R inhibitory oligonucleotides (INH-ODNs) for B-cell receptor-dependent activation of AM14 B cells induced with DNA-containing immune complexes. AM14 B cells were stimulated with (a) linear CpG-1826, (b) anti-nucleosome antibody PL2-3, or (c) lipopolysaccharide (LPS), and class R and class B INH-ODNs were added simultaneously. Proliferation of AM14 B cells was determined by measuring the [3H] thymidine incorporation for the last 6 hours. Results are expressed as percentage of maximal stimulation induced with the particular Toll-like receptor ligand (n = 3). *P < 0.05 (INH-1 versus INH-18). **P < 0.05 (INH-1 versus control).