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Figure 7 | Arthritis Research & Therapy

Figure 7

From: DNA-like class R inhibitory oligonucleotides (INH-ODNs) preferentially block autoantigen-induced B-cell and dendritic cell activation in vitro and autoantibody production in lupus-prone MRL-Faslpr/lprmice in vivo

Figure 7

Inhibitory oligonucleotides (INH-ODNs) prolong survival and decrease morbidity in MRL-Faslpr/lprmice in vivo. Pre-diseased MRL-Faslpr/lpr(2J strain) mice were treated with INH-1, INH-18, or vehicle starting from week 15 for 25 consecutive weeks. ODNs were injected intraperitoneally three times weekly at the concentration of 1 mg/kg body weight. Surviving mice were sacrificed at week 40. Similar results were obtained in three additional cohorts of lupus mice (J and 2J strains). Effects of INH-ODNs on survival (a), total lymph node weight (b), proteinuria (c), composite renal score (d), and IgG deposits in kidneys (e, f) are shown. *P < 0.05 (ODN-treated versus vehicle-treated). PBS, phosphate-buffered saline.

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Arthritis Research & Therapy

ISSN: 1478-6362

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