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Figure 8 | Arthritis Research & Therapy

Figure 8

From: DNA-like class R inhibitory oligonucleotides (INH-ODNs) preferentially block autoantigen-induced B-cell and dendritic cell activation in vitro and autoantibody production in lupus-prone MRL-Faslpr/lprmice in vivo

Figure 8

Class R inhibitory oligonucleotides (INH-ODNs) preferentially block autoantibody secretion in MRL-Faslpr/lprmice in vivo. Pre-diseased MRL-Faslpr/lprmice were treated with INH-1, INH-18, or vehicle for 25 weeks as in Figure 7. Surviving mice were sacrificed and their sera tested for autoantibodies. (a) The presence of anti-double-stranded DNA (anti-dsDNA) antibodies binding native DNA was determined semi-quantitatively by staining the Crithidia lucillae kinetoplasts. (b) The concentrations of anti-DNA and anti-Sm/RNP antibodies were further measured in enzyme-linked immunosorbent assay. *P < 0.05 (ODN-treated versus vehicle-treated). PBS, phosphate-buffered saline.

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Arthritis Research & Therapy

ISSN: 1478-6362

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