TY - JOUR AU - Rosa, Susana C. AU - Gonçalves, Juliana AU - Judas, Fernando AU - Mobasheri, Ali AU - Lopes, Celeste AU - Mendes, Alexandrina F. PY - 2009 DA - 2009/06/02 TI - Impaired glucose transporter-1 degradation and increased glucose transport and oxidative stress in response to high glucose in chondrocytes from osteoarthritic versus normal human cartilage JO - Arthritis Research & Therapy SP - R80 VL - 11 IS - 3 AB - Disorders that affect glucose metabolism, namely diabetes mellitus (DM), may favor the development and/or progression of osteoarthritis (OA). Thus far, little is known regarding the ability of chondrocytes to adjust to variations in the extracellular glucose concentration, resulting from hypoglycemia and hyperglycemia episodes, and so, to avoid deleterious effects resulting from deprivation or intracellular accumulation of glucose. The aim of this study was to compare the ability of normal and OA chondrocytes to regulate their glucose transport capacity in conditions of insufficient or excessive extracellular glucose and to identify the mechanisms involved and eventual deleterious consequences, namely the production of reactive oxygen species (ROS). SN - 1478-6354 UR - https://doi.org/10.1186/ar2713 DO - 10.1186/ar2713 ID - Rosa2009 ER -