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Table 2 RT-PCR expression levels of neurotrophins and receptors in the synovial fluids of SpA, RA, and OA patients

From: Nerve growth factor and receptor expression in rheumatoid arthritis and spondyloarthritis

Patient Groups   RT-PCR results
   TrkA p75 trkB trkC NGF BDNF NT-3 NT-4  
SpA (n = 16) median 20 13.4 6.7 7.1 323 92 7.0 7.3  
  SD 12 7.7 3.9 6.0 296 113 2.9 5.0  
  (range) (3.6 to 45) (3.5 to 28) (1.1 to 17) (2.4 to 25) (74 to 1225) (71 to 444) (1.3 to 9.6) (1 to 15)  
RA (n = 9) median 16 25 7.7 11 418 163 7.5 10  
  SD 10 12 4.3 3.4 275 101 3.5 7 to 6  
  (range) (8.9 to 40) (2.3 to 41) (4.1 to 18) (4.3 to 14) (267 to 1104) (71 to 374) (0.5 to 11) (4.9 to 22)  
OA (n = 7) median 4.7 4.8 4.1 6.7 49 137 3.4 8.6  
  SD 4.2 3.7 2.8 3.8 37.7 98.5 2.2 3.1  
  (range) (1.7 to 15) (3.2 to 15) (1.3 to 9.8) (3.2 to 15) (18 to 129) (25 to 238) (1.7 to 7.8) (4.3 to 13)  
  1. Table 2 shows the RT-PCR expression levels of mRNA transcripts of four neurotrophins (nerve growth factor (NGF), brain-derived growth factor (BDNF), and neurotrophin (NT)-3, NT-4) and their corresponding receptors (high-affinity receptors tyrosine kinase (trk)A, trkB, trkC and the low-affinity NGF receptor p75) of all 32 patients are shown (see also Figures 1 and 2 for detailed data and statistics).
  2. DD = disease duration given in years; ESR = erythrocyte sedimentation rate; f = female; m = male; PMN = percentage of polymorphonuclear cells of SF leukocytes; OA = osteoarthritis; RA = rheumatoid arthritis; SD = standard deviation; SpA = spondyloarthritis.