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Figure 5 | Arthritis Research & Therapy

Figure 5

From: Expression of 5-lipoxygenase and 15-lipoxygenase in rheumatoid arthritis synovium and effects of intraarticular glucocorticoids

Figure 5

Intraarticular glucocorticoids effects on lipoxygenase expression in rheumatoid arthritis synovium. Intraarticular glucocorticoids decrease 5-lipoxygenase (5-LO) expression in rheumatoid arthritis (RA) synovium but leave unaltered the expression of 15-LO-1 enzyme. RA synovial tissue (n = 11) showing diaminobenzidine (brown) staining for 5-LO (a) before and (b) after treatment, and for 15-LO-1 (d) before and (e) after therapy (hematoxylin counterstained). Graphs show image analysis results for (c) 5-LO and (f) 15-LO-1 expression in synovial biopsy sections taken before and after intraarticular corticosteroid injection. Results expressed as percentage of the total area of counterstained tissue. Horizontal lines, median values; whiskers, range values. **P < 0.01. Original magnification: (a, b) ×125 and (c, d) ×160.

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