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Table 1 Percentage of positive immunostained Notch-1, Stro-1, VCAM-1, and Sox9 cells

From: Mesenchymal progenitor cell markers in human articular cartilage: normal distribution and changes in osteoarthritis

Molecule Zone Percentage positive (±SE)
   Normal OA Non-fibrillated OA Fibrillated OA clusters
Notch-1 Superficial 71.5 ± 3.2† 57.7 ± 9.0* 84.2 ± 3.7†**# 83.6 ± 7.0 (1/5¶)
Normal (n = 8)Δ
OA NF (n = 5)
OA Fib (n = 5)
Middle 34.8 ± 6.7 48.9 ± 6.6* 61.6 ± 7.4†** 80.9 ± 7.2 (6/40)
  Deep 29.1 ± 6.9 28.2 ± 10.6† 10.4 ± 5.6†** 68.68 ± 7.2 (2/11)
      Mean: 78.5 ± 5.2
Stro-1 Superficial 81.3 ± 5.9† 84.7 ± 4.4† 82.9 ± 2.2 90.5 ± 9.5 (2/17)
Normal (n = 9)
OA NF (n = 8)
OA Fib (n = 4)
Middle 51.8 ± 7.6 56.8 ± 5.4† 71.2 ± 12.7 75.1 ± 14.7 (4/31)
  Deep 38.3 ± 12.3 42.0 ± 8.2† 42.8 ± 20.6† 37.0 ± 9.15§ (2/11)
      Mean: 69.4 ± 10.4
VCAM-1 Superficial 84.1 ± 1.3† 82.5 ± 4.7† 90.8 ± 5.5† 88.6 ± 7.7 (2/14)
Normal (n = 4)
OA NF (n = 6)
OA Fib (n = 4)
Middle 41.0 ± 8.9† 65.3 ± 4.4†* 66.5 ± 6.3** 76.5 ± 8.9 (3/24)
  Deep 15.7 ± 5.5† 44.5 ± 6.8†* 60.7 ± 11.3** 61.1 ± 3.7 (3/19)
      Mean: 75.4 ± 1.6
Sox9 Superficial 68.5 ± 6.9† 48.5 ± 8.8* 69.0 ± 5.3# 81.8 ± 5.2 (3/27)
Normal (n = 8)
OA NF (n = 8)
OA Fib (n = 6)
Middle 48.4 ± 6.1 43.2 ± 7.1 43.0 ± 8.6 73.5 ± 4.9 (4/30)
  Deep 38.0 ± 9.3 39.5 ± 11.3 18.5 ± 11.7# 25.6 ± 11.4§ (4/27)
      Mean: 71.6 ± 4.9
  1. Results show percentage positive cells for each zone in normal, non-fibrillated (NF), fibrillated (Fib) osteoarthritic (OA), and cells in OA cell clusters in human articular cartilage (number of donors).
  2. P < 0.05 between zone comparisons within each condition. * P < 0.05 between normal and non-fibrillated OA in the corresponding zone. ** P < 0.05 between normal and fibrillated OA in the corresponding zone. # P < 0.05 between non-fibrillated OA and fibrillated OA in the corresponding zone. ¶ (number of donors assessed/total number of clusters counted). § P < 0.05 between clusters in each zone within each condition. Δ Number of donors stained for each marker and condition.
  3. SE = standard error; VCAM-1 = vascular cell adhesion molecule-1.