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Table 4 Drugs approved by the Food and Drugs Administration for treatment of fibromyalgia

From: Developments in the scientific and clinical understanding of fibromyalgia

Drug

Class

Mechanism

Duloxetine

Antidepressant

Balanced norepinephrine and serotonin reuptake inhibition

Milnacipran

Antidepressant

Balanced norepinephrine and serotonin reuptake inhibition

Pregabalin

Anticonvulsant

α2δ ligand; affects calcium influx and release of excitatory amino acids and neuropeptides