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Table 4 Drugs approved by the Food and Drugs Administration for treatment of fibromyalgia

From: Developments in the scientific and clinical understanding of fibromyalgia

Drug Class Mechanism
Duloxetine Antidepressant Balanced norepinephrine and serotonin reuptake inhibition
Milnacipran Antidepressant Balanced norepinephrine and serotonin reuptake inhibition
Pregabalin Anticonvulsant α2δ ligand; affects calcium influx and release of excitatory amino acids and neuropeptides